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Table 1 Characteristics of enrolled patients

From: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial

Characteristics

HFNC (n = 44)

NIV (n = 42)

p value

Male, n (%)

27 (64.3)

23 (55.6)

0.259

Age, years

68.4 ± 9.3

71.4 ± 7.8

0.107

History of COPD, years

8 (5.3–10)

10 (6–12.3)

0.063

Smoking history, n (%)

20 (45.5)

26 (61.9)

0.126

 Current

8 (45.5)

11 (45.5)

0.371

Comorbidities, n (%)

 Diabetes mellitus

10 (22.7)

14 (33.3)

0.273

 Hypertension

25 (56.8)

17 (40.5)

0.130

 Coronary artery disease

13 (29.5)

16 (38.1)

0.402

 Chronic liver disease

2 (4.5)

5 (11.9)

0.260

 Chronic kidney disease

12 (27.3)

8 (19.0)

0.367

 Cerebrovascular disease

5 (11.4)

7 (16.7)

0.545

 Malignancy

6 (13.6)

3 (7.1)

0.325

Medication before exacerbation, n (%)

 Inhaled corticosteroids

11 (30.8)

15 (34.9)

0.280

 Beta adrenoceptor agonist

17 (38.6)

11 (26.2)

0.218

 Anticholinergics

5 (11.4)

8 (19.0)

0.320

Home oxygen therapy, n (%)

 NCO

8 (18.2)

5 (11.9)

0.417

 NIV

5 (11.4)

7 (16.7)

0.478

Lung function test before exacerbation (n = 52)*

 FEV1, %

41.3 ± 11.0

43.2 ± 12.6

0.577

 FEV1/FVC, %

40.9 ± 9.8

42.4 ± 9.6

0.580

APACHE II score

14 (11–18.8)

13 (10.8–16)

0.323

SAPS II score

27 (22–32.8)

30 (24–34.8)

0.138

NIV or HFNC before IMV, n (%)

 NIV

10 (22.7)

13 (31.0)

0.389

 HFNC

7 (15.9)

5 (11.9)

0.592

Characteristics at the PIC window

 Pressure support, cmH2O

11.7 ± 2.0

11.5 ± 1.7

0.584

 PEEP, cmH2O

5.5 (5–6)

6 (5–6)

0.512

 Tidal volume, mL

442.7 ± 57.7

431.2 ± 51.9

0.333

 Minute volume, L/min

8.5 ± 2.0

9.1 ± 2.5

0.292

 Respiratory frequency, /min

18 (16–23)

21 (16–26)

0.158

 Arterial pH

7.48 (7.42–7.51)

7.45 (7.40–7.49)

0.102

 PaCO2, mmHg

50.5 (48–57.8)

53 (48.8–61.3)

0.236

 PaO2/FiO2, mmHg

239.2 ± 47.0

229.3 ± 42.0

0.307

 Heart rate, beats/min

92 (80.5–107.8)

87.5 (80.8–101.5)

0.362

 Mean arterial pressure, mmHg

88 ± 6.0

84.5 ± 10.3

0.057

Duration of IMV, hours

98 (65.8–175.8)

114 (79.3–147.5)

0.792

FiO2 after extubation (stable)

0.32 (0.28–0.38)

0.35 (0.30–0.40)

0.447

  1. Data are shown as means ± standard deviation, number (%) patients, or median (interquartile range)
  2. HFNC high-flow nasal cannula oxygen therapy, NIV non-invasive ventilation, COPD chronic obstructive pulmonary disease, NCO nasal cannula oxygen, ICU intensive care unit, APACHE II Acute Physiology and Chronic Health Evaluation II, SAPS II Simplified Acute Physiology Score II, IMV invasive mechanical ventilation, PIC pulmonary infection control, PEEP positive end expiratory pressure, PaCO2 partial pressure of arterial carbon dioxide, PaO2 partial pressure of arterial oxygen, FiO2 fraction of inspiration oxygen
  3. *Twenty-five cases in the HFNC group and 27 cases in the NIV group
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Critical Care

ISSN: 1364-8535