Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study

Table 2 Independent risk factors for intensive care unit admission or all-cause mortality

Risk factors
Characteristic		Unadjusted OR (95%CI)		Adjusted OR (95%CI)		P
Age (years)		1.071 (1.066–1.076)		1.065 (1.059–1.071)		< 0.001
Sex (male)		1.755 (1.506–2.046)		1.896 (1.608–2.236)		< 0.001
Number of comorbidities						< 0.001
None
1		6.063 (5.076–7.242)		2.953 (2.450–3.560)		< 0.001
2		10.677 (8.389–13.589)		3.568 (2.768–4.599)		< 0.001
≥ 3		21.004 (14.960–29.491)		6.002 (4.206–8.566)		< 0.001
Examples of predicted probabilities
Age (years)	20		40		60		80
Sex	Male	Female	Male	Female	Male	Female	Male	Female
Number of comorbidities
0	0.002	0.001	0.007	0.004	0.025	0.014	0.083	0.046
1	0.006	0.003	0.021	0.011	0.071	0.039	0.211	0.124
2	0.007	0.004	0.026	0.014	0.084	0.046	0.244	0.146
≥ 3	0.012	0.007	0.042	0.023	0.134	0.075	0.351	0.222

OR risk ratio, 95%CI 95% confidence interval, ICU intensive care unit
Model: n total = 18,647, n events of ICU admission or all-cause mortality = 687; c-statistic of 0.876 (95%CI 0.866–0.887); Brier score of 0.0322
Probability of intensive care unit admission or all-cause mortality = e^y/(e^y + 1)
y = − 8.053 + 0.0627*Age (years) + 0.6374*Sex (male as one or female as zero) + A or B or C (A = 1.0786 if one comorbidity; B = 1.2668 if 2 comorbidities; C = 1.7847 if ≥ 3 comorbidities)

ISSN: 1364-8535