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Table 1 Patients’ characteristics and outcome of the study cohort and after propensity score matching

From: Neuromuscular blocking agents (NMBA) for COVID-19 acute respiratory distress syndrome: a multicenter observational study

  Study cohort Propensity score matched
≤ 2d N = 166 > 2d N = 241 P* value ≤ 2d N = 103 > 2d N = 103 P* value
Medical history
Age, median (IQR) 63 (56–71) 65 (55–72) 0.6 62 (56–70) 63 (55–72) 0.31
Gender, male,n(%) 123 (74) 191 (79) 0.23 71 (68) 82 (79) 0.11
Body mass index, median (IQR) 29 (26–32) 29 (26–33) 0.16 29 (27–33) 29 (26–32) 0.24
Chronic pulmonary disease,n(%) 25 (15) 33 (13) 0.77 14 (0.13) 11 (0.10) 0.67
Charlson score,n(%)
0 72 (43) 98 (41) 0.97 43 (41) 43 (41) 0.93
1 37 (22) 66 (27)   28 (27) 27 (26)  
≥ 2 57 (34) 77 (32)   32 (31) 33 (32)  
Country (France),n(%) 81 (48) 207 (85) < 0.001 68 (66) 85 (82) 0.49
Duration of symptoms, days median (IQR) 7 (3–9) 7 (4–9) 0.35 7 (5–9) 8 (5–10) 0.70
Respiratory values at baseline
PaO2/FiO2 ratio, median (IQR) 126 (88–162) 120 (87–157) 0.15 124 (87–154) 120 (81–154) 0.47
PaO2/FiO2 ratio < 120 mmHg,n(%) 55 (33) 78 (32) 0.87 37 (35) 39 (37) 0.77
Plateau pressure (cmH20), median (IQR) 23 (20–26) 24 (21–26) 0.07 23 (21–25) 24 (21–26) 0.9
Peep (cmH20), median (IQR) 12 (10–14) 11 (10–13) 0.38 12 (10–14) 12 (10–13) 0.32
Tidal volume, (mL/kg of IBW), median (IQR) 6.1 (5.8–6.8) 6.1 (5.8–6.6) 0.30 6.2 (5.8–6.8) 6.1 (5.8–6.7) 0.26
Driving pressure (cmH20), median (IQR) 11 (9–13) 12 (10–14) 0.07 11 (9–13) 11 (9–14) 0.91
Compliance of respiratory system (mL/cmH2O) median IQR 36.7 (30.7–44.4) 34.6 (27.7–45) 0.14 36.7 (30.2–40.3) 36.8 (28.4–46.7) 0.92
Prone position,n(%) 108 (65) 217 (90) < 0.001 80 (78) 82 (80) 0.86
Outcome
Breathing without assistance at day 28, n (%) 81 (49) 93 (38) 0.04 49 (47) 45 (43) 0.67
d14 ventilatory mode
Death 41 (25) 94 (39) 0.001 26 (25) 35 (34) 0.36
Controlled mode—ECMO 32 (19) 55 (23)   24 (23) 22 (21)  
Pressure support 50 (30) 41 (17)   30 (29) 21 (20)  
Extubated 42 (25) 51 (21)   23 (22) 25 (24)  
Needs for ECMO,n(%) 14 (8) 31 (13) 0.2 11 (11) 16 (15) 0.4
d28 VFDs, median (IQR) 0 (0–16) 0 (0–10) 0.005 0 (0–15.5) 0 (0–12.5) 0.25
ICU mortality 62 (38) 98 (41) 0.54 39 (38) 41 (42) 0.67
Length of MV in ICU survivors, median (IQR) 15 (9–26) 20 (13–32) 0.003 15 (9–27) 20 (13–31) 0.09
Hospital LOS** in ICU survivors, median (IQR) 30 (20–50) 36 (24–56) 0.07 31 (20–50) 38 (27–52) 0.13
  1. IQR interquartile range, SD standard deviation, VFD ventilatory-free days
  2. *P values were obtained from the Fisher test, t test, or Mann-Whitney test as appropriate
  3. **Censured at day 90