Table 1 Patients’ characteristics and outcome of the study cohort and after propensity score matching
Study cohort | Propensity score matched | |||||
|---|---|---|---|---|---|---|
≤ 2d N = 166 | > 2d N = 241 | P* value | ≤ 2d N = 103 | > 2d N = 103 | P* value | |
Medical history | ||||||
Age, median (IQR) | 63 (56–71) | 65 (55–72) | 0.6 | 62 (56–70) | 63 (55–72) | 0.31 |
Gender, male,n(%) | 123 (74) | 191 (79) | 0.23 | 71 (68) | 82 (79) | 0.11 |
Body mass index, median (IQR) | 29 (26–32) | 29 (26–33) | 0.16 | 29 (27–33) | 29 (26–32) | 0.24 |
Chronic pulmonary disease,n(%) | 25 (15) | 33 (13) | 0.77 | 14 (0.13) | 11 (0.10) | 0.67 |
Charlson score,n(%) | ||||||
0 | 72 (43) | 98 (41) | 0.97 | 43 (41) | 43 (41) | 0.93 |
1 | 37 (22) | 66 (27) | 28 (27) | 27 (26) | ||
≥ 2 | 57 (34) | 77 (32) | 32 (31) | 33 (32) | ||
Country (France),n(%) | 81 (48) | 207 (85) | < 0.001 | 68 (66) | 85 (82) | 0.49 |
Duration of symptoms, days median (IQR) | 7 (3–9) | 7 (4–9) | 0.35 | 7 (5–9) | 8 (5–10) | 0.70 |
Respiratory values at baseline | ||||||
PaO2/FiO2 ratio, median (IQR) | 126 (88–162) | 120 (87–157) | 0.15 | 124 (87–154) | 120 (81–154) | 0.47 |
PaO2/FiO2 ratio < 120 mmHg,n(%) | 55 (33) | 78 (32) | 0.87 | 37 (35) | 39 (37) | 0.77 |
Plateau pressure (cmH20), median (IQR) | 23 (20–26) | 24 (21–26) | 0.07 | 23 (21–25) | 24 (21–26) | 0.9 |
Peep (cmH20), median (IQR) | 12 (10–14) | 11 (10–13) | 0.38 | 12 (10–14) | 12 (10–13) | 0.32 |
Tidal volume, (mL/kg of IBW), median (IQR) | 6.1 (5.8–6.8) | 6.1 (5.8–6.6) | 0.30 | 6.2 (5.8–6.8) | 6.1 (5.8–6.7) | 0.26 |
Driving pressure (cmH20), median (IQR) | 11 (9–13) | 12 (10–14) | 0.07 | 11 (9–13) | 11 (9–14) | 0.91 |
Compliance of respiratory system (mL/cmH2O) median IQR | 36.7 (30.7–44.4) | 34.6 (27.7–45) | 0.14 | 36.7 (30.2–40.3) | 36.8 (28.4–46.7) | 0.92 |
Prone position,n(%) | 108 (65) | 217 (90) | < 0.001 | 80 (78) | 82 (80) | 0.86 |
Outcome | ||||||
Breathing without assistance at day 28, n (%) | 81 (49) | 93 (38) | 0.04 | 49 (47) | 45 (43) | 0.67 |
d14 ventilatory mode | ||||||
Death | 41 (25) | 94 (39) | 0.001 | 26 (25) | 35 (34) | 0.36 |
Controlled mode—ECMO | 32 (19) | 55 (23) | 24 (23) | 22 (21) | ||
Pressure support | 50 (30) | 41 (17) | 30 (29) | 21 (20) | ||
Extubated | 42 (25) | 51 (21) | 23 (22) | 25 (24) | ||
Needs for ECMO,n(%) | 14 (8) | 31 (13) | 0.2 | 11 (11) | 16 (15) | 0.4 |
d28 VFDs, median (IQR) | 0 (0–16) | 0 (0–10) | 0.005 | 0 (0–15.5) | 0 (0–12.5) | 0.25 |
ICU mortality | 62 (38) | 98 (41) | 0.54 | 39 (38) | 41 (42) | 0.67 |
Length of MV in ICU survivors, median (IQR) | 15 (9–26) | 20 (13–32) | 0.003 | 15 (9–27) | 20 (13–31) | 0.09 |
Hospital LOS** in ICU survivors, median (IQR) | 30 (20–50) | 36 (24–56) | 0.07 | 31 (20–50) | 38 (27–52) | 0.13 |