Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING)

Table 3 Primary and secondary outcome parameters according to ventilation mode (CV conventional ventilation, AV automated ventilation)

Outcome parameters	CV period n = 265	AV period n = 265	p
Primary outcome
Time spent with SpO₂ in the acceptable range—% of DNP duration*	43 ± 37 (38–47)	48 ± 37 (43–52)	0.03
Secondary outcome
Patients with SpO₂ in the acceptable range during DNP—n (%)*	123 (46%)	160 (60%)	0.001
Patients with at least one episode of:
SpO₂ ≤ 85%**—n (%)	50 (19%)	30 (11%)	0.02
SpO₂ < 90%**—n (%)	92 (35%)	69 (26%)	0.03
Time spent with:
SpO₂ ≤ 85%—% of DNP duration	3 ± 8 (2–4)	2 ± 6 (1–2)	0.03
SpO₂ < 90%—% of DNP duration	6 ± 11 (5–7)	5 ± 12 (3–6)	0.02
FiO₂ 100%—% of DNP duration	6 ± 12 (4–7)	4 ± 10 (3–6)	0.09
SpO_{2 mean}—%	95 ± 3 (95–95)	95 ± 3 (95–95)	0.81
SpO_{2 min}—%	91 ± 6 (90–91)	91 ± 8 (90–92)	0.20
SpO_{2 max}—%	97 ± 2 (97–98)	97 ± 2 (97–98)	0.63

Categorical variables are expressed as n (%) and continuous variables as mean ± standard deviation (95% confidence interval)
DNP daily nursing procedure, SpO₂ blood oxygen pulse saturation, FiO₂ fraction of inspired oxygen, SpO_{2 mean} mean SpO₂ during DNP, SpO_{2 min} minimal SpO₂ recorded during DNP, SpO_{2 max} maximal SpO₂ recorded during DNP
*SpO₂ acceptable range was ≥ 90 and ≤ 95%
**For more than 1 min

ISSN: 1364-8535