Fig. 2

Circular RNA expression in patients with sepsis due to CAP relative to healthy subjects. a Barplot illustrating the average circRNA expression in monocytes (CD14), CD4, CD8 T cells, and B cells (CD19) of CAP patients and healthy volunteers. b Volcano plot representing the differentially expressed circRNA of each peripheral mononuclear cell type in CAP as compared to the health. The horizontal dotted line represents the nominal p value ≤ 0.05 threshold. A horizontal solid line represents the multiple-comparison adjusted p value ≤ 0.05 threshold. Red dots, upregulated circRNA (nominal p < 0.05); blue dots, downregulated circRNA (nominal p < 0.05); gray dots, not altered circRNA (nominal p > 0.05). c Representative UCSC genome browser of the exons corresponding to the two significantly altered (adjusted p value < 0.05) circRNAs in monocytes of CAP patients relative to healthy patients. The presence of Alu repeats in the flanking introns is noted. E, exon; Alu, Arthrobacter luteus restriction endonuclease repeats. d Venn diagram of differentially abundant circRNAs (nominal p < 0.05) per cell type. e Venn diagram of differentially expressed (adjusted p < 0.05) linear mRNA species in monocytes, CD4, CD8 T cells, and B cells (CD19) of CAP patients relative to healthy subjects