Skip to main content

Table 1 Adjustment of unfractionated heparin dose during ECMO according to anti-Xa activity and body weight. 20,000 IU UFH + 44 cc NaCl 0.9%

From: Use of multiple laboratory tests including anti-factor Xa to optimally manage anticoagulation during ECMO

Anti-Xa activity Bolus Variation 55–64 kg 65–74 kg 75–84 kg 85–94 kg 95–104 kg 105–114 kg 115–124 kg
< 0.2 26 U/kg ↑96 U/kg/h ↑0.6 cc/h ↑0.7 cc/h ↑0.8 cc/h ↑0.9 cc/h ↑1 cc/h ↑1.1 cc/h ↑1.2 cc/h
0.20–0.29 No ↑48 U/kg/h ↑0.3 cc/h ↑0.3 cc/h ↑0.4 cc/h ↑0.4 cc/h ↑0.5 cc/h ↑0.6 cc/h ↑0.7 cc/h
0.30–0.70 No         
0.71–0.80 No ↓24 U/kg/h ↓0.1 cc/h ↓0.1 cc/h ↓0.2 cc/h ↓0.2 cc/h ↓0.2 cc/h ↓0.3 cc/h ↓0.3 cc/h
0.81–0.99 No ↓48 U/kg/h ↓0.3 cc/h ↓0.3 cc/h ↓0.4 cc/h ↓0.4 cc/h ↓0.5 cc/h ↓0.6 cc/h ↓0.7 cc/h
> 1 No ↓96 U/kg/h ↓0.6 cc/h ↓0.7 cc/h ↓0.8 cc/h ↓0.9 cc/h ↓1.0 cc/h ↓1.1 cc/h ↓1.2 cc/h
  1. The table can be adapted: For 30,000 IU of UFH, use a correction factor of 1.5. For 40,000 IU of UFH, use a correction factor of 2. For 50,000 IU of UFH, use a correction factor of 2.5