Table 2 Primary and secondary outcomes
Outcomes | Total n = 80 | Standard of care n = 22 | Lopinavir/ritonavir n = 20 | Hydroxychloroquine n = 38 | p value |
|---|---|---|---|---|---|
Treatment escalation after day 1 until day 28, n (%) | 34 (43) | 9 (41) | 10 (50) | 15 (39) | 0.731 |
Intubation, n (%) | 8 (10) | 2 (9) | 1 (5) | 5 (13) | 0.607 |
ECMO, n (%) | 13 (16) | 4 (18) | 4 (20) | 5 (13) | 0.766 |
Renal replacement therapy, n (%) | 19 (24) | 4 (18) | 8 (40) | 7 (18) | 0.143 |
Time between ICU admission and treatment escalation, days | 5 (3–7) | 6 (4–9) | 5 (3–8) | 3 (2–7) | 0.441 |
Ventilator-free days at day 28 | 7 (0–22) | 0 (0–23) | 9 (0–16) | 9 (0–23) | 0.546 |
14-day mortality, n (%) | 22 (28) | 9 (41) | 5 (25) | 8 (21) | 0.242 |
28-day mortality, n (%) | 25 (31) | 9 (41) | 7 (35) | 9 (24) | 0.350 |