| Sham | CLP-NaCl | CLP-HSL | p value | |
---|---|---|---|---|---|
Sham vs. NaCl | HSL vs. NaCl | ||||
Blood ionogram (n = 6) | |||||
 Na+ (mmol/L) | 138 [138–143] | 141 [140–143] | 153 [150–157] | 1 | 0.02 |
 K+ (mmol/L) | 4.8 [4.5–5.0] | 4.7 [4.2–5.2] | 3.7 [3.1–4.0] | 1 | 0.02 |
 Cl− (mmol/L) | 98 [96–99] | 100 [99–101] | 97 [94–99] | 1 | 0.02 |
 Urea (mmol/L) | 6.9 [5.7–8.3] | 16.2 [11.3–24.6] | 9.6 [8.5–10.7] | < 0.0001 | 0.04 |
Urine ionogram (n = 6) | |||||
 Na+ (mmol/L) | 149 [58–163] | 26 [21–39] | 441 [362–509] | 0.2 | 0.0004 |
 Na+ (mmol/day) | 2.5 [2.1–2.8] | 0.1 [0.1–0.1] | 9.9 [8.2–12.5] | 0.1 | 0.0003 |
 ∆Na+ (mmol) |  | 2.4 [2.4–2.8] | 4.9 [2.7–6.2] |  | 0.06 |
 K+ (mmol/L) | 254 [196–282] | 325 [295–406] | 104 [88–142] | 0.2 | 0.0005 |
 K+ (mmol/day) | 4.6 [3.9–4.8] | 1.3 [0.7–2.2] | 2.6 [2.0–2.9] | 0.001 | 0.3 |
 ∆K+ (mmol) |  | − 1.3 [0.7–2.2] | − 2.6 [2.0–2.9] |  |  |
 Cl− (mmol/L) | 185 [143–231] | 89 [67–126] | 107 [85–137] | 0.02 | 0.8 |
 Cl− (mmol/day) | 3.4 [2.9–3.7] | 0.3 [0.1–0.8] | 2.5 [1.9–3.2] | 0.002 | 0.03 |
 ∆Cl− (mmol) |  | 2.2 [2.0–2.4] | − 2.5 [1.9–3.2] |  | 0.002 |
Blood metabolic parameters (n = 10) | |||||
 Glucose (mmol/L, n = 10) | 10.5 ± 2.4 | 4.9 ± 1.1 | 9.4 ± 4.5 | 0.0006 | 0.002 |
 Lactate (mmol/L) | 1.6 ± 1.0 | 3.5 ± 1.5 | 6.7 ± 4.6 | 0.1 | 0.04 |
 Pyruvate (μmol/L) | 32 ± 22 | 122 ± 51 | 249 ± 186 | 0.09 | 0.03 |
 Lactate/pyruvate ratio | 51 [34–97] | 28 [17–37] | 24 [17–31] | 0.06 | 1 |
 3-Hydroxybutyrate (μmol/L) | 514 ± 249 | 212 ± 105 | 445 ± 303 | 0.02 | 0.03 |
 Acetoacetate (μmol/L) | 317 ± 198 | 149 ± 77 | 216 ± 137 | ns | |
Blood inflammation and capillary leakage parameters (n = 10) | |||||
 IL-1β (pg/mL) | 48 ± 11 | 993 ± 851 | 272 ± 215 | 0.0006 | 0.004 |
 TNFα (pg/mL) | 6 ± 2 | 59 ± 31 | 28 ± 23 | < 0.0001 | 0.005 |
 IL-10 (pg/mL) | 207 ± 29 | 1015 ± 389 | 601 ± 523 | 0.0001 | 0.02 |
 VEGF-A (pg/mL) | 240 [226–280] | 261 [250–287] | 198 [185–250] | 0.4 | 0.009 |
 Syndecan-1 (pg/mL) | 8.5 ± 4.0 | 9.7 ± 2.6 | 7.7 ± 2.0 | ns | |
 Albumin (g/L) | 25.6 ± 2.2 | 22.2 ± 2.2 | 23 ± 2.6 | 0.001 | 0.4 |