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Table 6 Associations between independent variables and outcomes. All outcomes were analysed in separate multivariable regression models as described in the “Methods” section. Morbidity outcomes were reported for the first 28 days after admission

From: Morbidity and mortality in critically ill patients with invasive group A streptococcus infection: an observational study

Outcome

Age

SAPS 3a

iGAS

Severe sepsis or septic shock, n = 1021

 Mortality, CIb of HRc

1.002–1.016*

1.032–1.044*

0.204–0.746*

 DAFd vasopressor, CIb of ORe

0.994–1.015

1.044–1.07*

0.897–3.681

 DAFd ventilator CIb of ORe

0.977–0.997*

1.046–1.070*

0.694–2.330

 CRRTf, CIb of ORe

0.979–1.002

1.031–1.054*

0.862–3.416

 AKIN-creag, CIb of ORe

0.985–1.003

1.030–1.050*

1.246–4.968*

  1. aSimplified Acute Physiology Score 3
  2. bConfidence interval (95%)
  3. cHazard ratio
  4. dDays alive and free
  5. eOdds ratio
  6. fContinuous renal replacement therapy
  7. gAcute Kidney Injury Network (AKIN)-creatinine class 1 or worse
  8. *p ≤ 0.05
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Critical Care

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