Fig. 1
From: Interpreting trials on renal replacement therapy initiation: beware of methodologic issues
Different study designs to evaluate the timing of initiation of kidney replacement therapy in acute kidney injury. a Observational studies do not include patients with AKI who never receive RRT. b Randomized controlled trials adequately answer clinical question of timing of RRT in AKI. Not all patients included in the late initiation strategy actually will receive RRT. Adapted with permission from Palevsky et al. [6]