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Table 2 Perioperative changes in sublingual total vessel density (TVD), small vessel density (SVD), and vessel density (VD) per study

From: Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review

Study

n

Technique

Study groups

Pre-CBP

CPB

Post-CPB

Induction

Onset of CPB

Late phase of CPB

Post-CPB

ICU

24 h after surgery

Bienz et al. [28]

16

SDF

CABG

~ TVD

~ TVD

~ TVD

~ TVD

~ TVD

–

  

CABG

~ SVD

~ SVD

↑ SVD

~ SVD

~ SVD

–

De Backer et al. [14]

9

OPS

Cardiac surgery with CPB

~ VD

~ VD

–

~ VD

~ VD

~ VD

Holmgaard et al. [21]

30

SDF

CABG with HMAP

–

~ TVD

–

~ TVD

–

–

  

CABG with LMAP

–

~ TVD

–

~ TVD

–

–

Koning et al. [24]

33

SDF

CABG non pulsatile CPB

–

~ TVD

~ TVD

~ TVD

~ TVD

–

  

CABG pulsatile CPB

–

~ TVD

~ TVD

~ TVD

~ TVD

–

Koning et al. [31]

13

SDF

CABG

–

↓ TVD

↓ TVD

↓ TVD

↓ TVD

–

Mohamed et al. [22]

70

SDF

CABG with regular anesthesia

–

~ TVD

–

~ TVD

–

–

  

CABG dexmed anesthesia

–

~ TVD

–

↓ TVD

–

–

Özarslan et al. [20]

30

OPS

CABG sevoflurane anesthesia

~ TVD

↓ TVD

–

~ TVD

–

~ TVD

  

CABG isoflurane anesthesia

~ TVD

↓ TVD

–

~ TVD

–

~ TVD

  

CABG desflurane anesthesia

~ TVD

~ TVD

–

~ TVD

–

~ TVD

Prestes et al. [23]

22

SDF

CS with CPB

–

~ VD

~

~ TVD

–

–

  1. A downward facing arrow (↓) represents a significant decrease compared to baseline measurement. An upward facing arrow (↑) represents a significant increase compare to baseline measurement. ~ represents no significant change compared to baseline value. TVD total vessel density, VD vessel density, SMD small vessel density, CPB cardiopulmonary bypass, SDF side-stream dark field imaging, OPS orthogonal polarization spectral imaging, n number of participants, h hours, CS cardiac surgery, CABG coronary artery bypass grafting, LMAP low mean arterial pressure, HMAP high mean arterial pressure