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Table 2 Ventilation settings and hemodynamics—standard protocol-based cohort and lung rescue team cohort

From: A lung rescue team improves survival in obesity with acute respiratory distress syndrome

Variable

Group

Day 1

Day 2

Day 3

Day 4

PEEP, cmH2O , mean (CI 95%)

Standard protocol-based cohort

9 (8–10)

P = 0.20

9 (8–10)

P < 0.001

9 (8–10)

P < 0.001

9 (8–10)

P < 0.001

Lung rescue team cohort

9 (9–10)

19 (18–20)

20 (18–21)

20 (18–21)

TV/IBW, mL/kg , mean (CI 95%)

Standard protocol-based cohort

6.4 (6.2–6.6)

P = 0.33

6.5 (6.3–6.8)

P = 0.10

6.4 (6.1–6.6)

P = 0.21

6.5 (6.3–6.7)

P = 0.11

Lung rescue team cohort

6.2 (5.9–6.5)

6.2 (5.9–6.5)

6.2 (5.9–6.5)

6.2 (5.9–6.6)

DPa, cmH2O, mean (CI 95%)

Standard protocol-based cohort

13 (12.1–14.1)

P = 0.94

13 (12.2–14.8)

P < 0.001

13 (11.9–15.2)

P < 0.001

13 (11.8–15.1)

P < 0.001

Lung rescue team cohort

13 (12.0–14.3)

10 (8.7–10.4)

9 (8.2–9.9)

8 (7.3–9.6)

CRSb, mL/cmH2O, mean (CI 95%)

Standard protocol-based cohort

35 (31–38)

P = 0.41

33 (27–39)

P < 0.001

36 (27–46)

P = 0.003

33 (27–40)

P = 0.002

Lung rescue team cohort

33 (29.7–37.1)

45 (41–49)

48 (41–56)

52 (42–62)

Pa/FiO2, mmHg, mean (CI 95%)

Standard protocol-based cohort

197 (177–217)

P = 0.003

224 (203–245)

P = 0.001

220 (199–242)

P = 0.004

218 (194–242)

P = 0.004

Lung rescue team cohort

154 (127–179)

282 (252–312)

284 (256–312)

276 (243–309)

RIV No. (%)

Standard protocol-based cohort

49/70 (70)

P = 0.47

51/70 (73)

P = 0.30

41/70 (58)

P = 0.04

39/70 (56)

P = 0.005

Lung rescue team cohort

38/50 (76)

32/50 (64)

20/50 (40)

15/50 (30)

VIS , mean (CI 95%)

Standard protocol-based cohort

16 (11–21)

P = 0.79

15 (10–20)

P = 0.14

14 (9–20)

P = 0.004

15 (6–24)

P = 0.001

Lung rescue team cohort

15 (9–21)

9 (5–12)

5 (2–8)

4 (1–8)

  1. Abbreviations: PEEP positive end-expiratory pressure, CI confidence interval, TV tidal volume, IBW ideal body weight, DP driving pressure, CRS compliance of respiratory system, RIV requirement for inotropics and vasopressors, VIS vasoactive-inotropic score
  2. aDriving pressure is difference between plateau pressure (measured at the end of an end-inspiratory pause) and total positive end-expiratory pressure (measured at the end of an end-expiratory pause)
  3. bRespiratory system compliance is the ratio of tidal volume to driving pressure
  4. Information at days 3 and 4 were available for more than 80% of patients and statistics were performed only on available data
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Critical Care

ISSN: 1364-8535