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Table 2 Ventilation settings and hemodynamics—standard protocol-based cohort and lung rescue team cohort

From: A lung rescue team improves survival in obesity with acute respiratory distress syndrome

VariableGroupDay 1Day 2Day 3Day 4
PEEP, cmH2O , mean (CI 95%)Standard protocol-based cohort9 (8–10)P = 0.209 (8–10)P < 0.0019 (8–10)P < 0.0019 (8–10)P < 0.001
Lung rescue team cohort9 (9–10)19 (18–20)20 (1821)20 (18–21)
TV/IBW, mL/kg , mean (CI 95%)Standard protocol-based cohort6.4 (6.2–6.6)P = 0.336.5 (6.3–6.8)P = 0.106.4 (6.16.6)P = 0.216.5 (6.3–6.7)P = 0.11
Lung rescue team cohort6.2 (5.9–6.5)6.2 (5.9–6.5)6.2 (5.9–6.5)6.2 (5.9–6.6)
DPa, cmH2O, mean (CI 95%)Standard protocol-based cohort13 (12.1–14.1)P = 0.9413 (12.2–14.8)P < 0.00113 (11.9–15.2)P < 0.00113 (11.8–15.1)P < 0.001
Lung rescue team cohort13 (12.0–14.3)10 (8.7–10.4)9 (8.2–9.9)8 (7.3–9.6)
CRSb, mL/cmH2O, mean (CI 95%)Standard protocol-based cohort35 (31–38)P = 0.4133 (27–39)P < 0.00136 (2746)P = 0.00333 (27–40)P = 0.002
Lung rescue team cohort33 (29.7–37.1)45 (41–49)48 (41–56)52 (42–62)
Pa/FiO2, mmHg, mean (CI 95%)Standard protocol-based cohort197 (177–217)P = 0.003224 (203–245)P = 0.001220 (199–242)P = 0.004218 (194–242)P = 0.004
Lung rescue team cohort154 (127–179)282 (252–312)284 (256–312)276 (243–309)
RIV No. (%)Standard protocol-based cohort49/70 (70)P = 0.4751/70 (73)P = 0.3041/70 (58)P = 0.0439/70 (56)P = 0.005
Lung rescue team cohort38/50 (76)32/50 (64)20/50 (40)15/50 (30)
VIS , mean (CI 95%)Standard protocol-based cohort16 (1121)P = 0.7915 (10–20)P = 0.1414 (9–20)P = 0.00415 (6–24)P = 0.001
Lung rescue team cohort15 (9–21)9 (5–12)5 (2–8)4 (1–8)
  1. Abbreviations: PEEP positive end-expiratory pressure, CI confidence interval, TV tidal volume, IBW ideal body weight, DP driving pressure, CRS compliance of respiratory system, RIV requirement for inotropics and vasopressors, VIS vasoactive-inotropic score
  2. aDriving pressure is difference between plateau pressure (measured at the end of an end-inspiratory pause) and total positive end-expiratory pressure (measured at the end of an end-expiratory pause)
  3. bRespiratory system compliance is the ratio of tidal volume to driving pressure
  4. Information at days 3 and 4 were available for more than 80% of patients and statistics were performed only on available data