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Table 2 Meta-analysis of rs10865710 association with sepsis and organ dysfunction in trauma patients

From: Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression

  

Sepsis/non-sepsis

MOD score

Author

N

CC

CG

GG

CC

CG

GG

Internal test

797

106/244

130/223

42/52

4.8 ± 2.1

5.7 ± 2.2

6.0 ± 2.6

External validation

334

44/100

63/90

17/20

4.1 ± 3.5

4.9 ± 3.2

6.2 ± 2.9

Gao 2016*

734

123/193

136/192

53/37

4.8 ± 2.2

4.8 ± 1.9

5.6 ± 2.4

Meta-analysis

1865

a1, b1, c1

a2, b2

  1. *Represented our previous study
  2. a: Dominant effect (GG + CG versus CC) as analyzed by analysis of covariance, a1P = 0.0004, OR = 1.41, 95% CI = 1.17–1.71, I2 = 0, Phet = 0.67; a2P = 0.02, MD = 0.70 score, 95% CI = 0.09–1.31, I2 = 86%, Phet = 0.001
  3. b: Recessive effect (GG versus CG + CC) as analyzed by analysis of covariance, b1P < 0.0001, OR = 1.78, 95% CI = 1.34–2.36, I2 = 0, Phet = 0.59; a2P < 0.0001, MD = 0.91 score, 95% CI = 0.56–1.27, I2 = 26%, Phet = 0.26
  4. c: Allelic effect (G versus C) as analyzed by analysis of covariance, c1P < 0.0001, OR = 1.38, 95% CI = 1.20–1.58, I2 = 0, Phet = 0.97
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Critical Care

ISSN: 1364-8535