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Table 1 Clinical relevance of the rs10865710C/G in patients with major trauma

From: Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression

CohortsGenotypeNAge yearsGender M/F (%)ISSSepsis, n (%)MOD score
Internal testCC35043.1 ± 13.3278 (79.4%)/72 (20.6%)22.4 ± 7.6106 (30.3)4.8 ± 2.1
CG35343.0 ± 12.3284 (80.5%)/69 (19.5%)22.5 ± 8.3130 (36.8)5.7 ± 2.2
GG9442.0 ± 12.483 (88.3%)/11 (11.7%)23.7 ± 8.042 (44.7)6.0 ± 2.6
      a1, b1, c1a2, d1
External validationCC14438.4 ± 12.6112 (77.8%)/32 (22.2%)23.3 ± 9.944 (30.6)4.1 ± 3.5
CG15338.1 ± 12.4129 (84.3%)/24 (15.7%)24.8 ± 8.763 (41.2)4.9 ± 3.2
GG3740.5 ± 11.731 (83.8%)/6 (16.2%)23.0 ± 8.417 (45.9)6.2 ± 2.9
      a3, c2a4, b2, d2
  1. Age, ISS, and cytokine are given as mean ± standard deviation; MOD score is given as mean ± standard error
  2. F female, ISS Injury Severity Score, M male, MOD multiple organ dysfunction
  3. a: Dominant effect (GG + CG versus CC) as analyzed by analysis of covariance, a1P = 0.016, a2P = 0.0005, a3P = 0.03, a4P = 0.009
  4. b: Recessive effect (GG versus CG + CC) as analyzed by analysis of covariance, b1P = 0.034, b2P = 0.024
  5. c: The relative risk of sepsis as analyzed by logistic regression analyses, adjusting for age, sex, and injury severity for confounding effects, c1P = 0.004, OR = 1.41, 95% CI = 1.11–1.79; c2P = 0.046, OR = 1.45, 95% CI = 1.01–2.09
  6. d: The relative risk of MOD score as analyzed by linear regression analyses, adjusting for age, sex, and injury severity for confounding effects, d1P = 0.002, d2P = 0.002