Cohorts | Genotype | N | Age years | Gender M/F (%) | ISS | Sepsis, n (%) | MOD score |
|---|
Internal test | CC | 350 | 43.1 ± 13.3 | 278 (79.4%)/72 (20.6%) | 22.4 ± 7.6 | 106 (30.3) | 4.8 ± 2.1 |
CG | 353 | 43.0 ± 12.3 | 284 (80.5%)/69 (19.5%) | 22.5 ± 8.3 | 130 (36.8) | 5.7 ± 2.2 |
GG | 94 | 42.0 ± 12.4 | 83 (88.3%)/11 (11.7%) | 23.7 ± 8.0 | 42 (44.7) | 6.0 ± 2.6 |
| | | | | | | a1, b1, c1 | a2, d1 |
External validation | CC | 144 | 38.4 ± 12.6 | 112 (77.8%)/32 (22.2%) | 23.3 ± 9.9 | 44 (30.6) | 4.1 ± 3.5 |
CG | 153 | 38.1 ± 12.4 | 129 (84.3%)/24 (15.7%) | 24.8 ± 8.7 | 63 (41.2) | 4.9 ± 3.2 |
GG | 37 | 40.5 ± 11.7 | 31 (83.8%)/6 (16.2%) | 23.0 ± 8.4 | 17 (45.9) | 6.2 ± 2.9 |
| | | | | | | a3, c2 | a4, b2, d2 |
- Age, ISS, and cytokine are given as mean ± standard deviation; MOD score is given as mean ± standard error
- F female, ISS Injury Severity Score, M male, MOD multiple organ dysfunction
- a: Dominant effect (GG + CG versus CC) as analyzed by analysis of covariance, a1P = 0.016, a2P = 0.0005, a3P = 0.03, a4P = 0.009
- b: Recessive effect (GG versus CG + CC) as analyzed by analysis of covariance, b1P = 0.034, b2P = 0.024
- c: The relative risk of sepsis as analyzed by logistic regression analyses, adjusting for age, sex, and injury severity for confounding effects, c1P = 0.004, OR = 1.41, 95% CI = 1.11–1.79; c2P = 0.046, OR = 1.45, 95% CI = 1.01–2.09
- d: The relative risk of MOD score as analyzed by linear regression analyses, adjusting for age, sex, and injury severity for confounding effects, d1P = 0.002, d2P = 0.002
