Table 3 Hazard ratios expressing the risk of death in relation to risk factors and biomarkers in 1243 ICU survivors
From: A novel urinary biomarker predicts 1-year mortality after discharge from intensive care
Risk factors | Hazard ratio (95% CI) | P |
|---|---|---|
Number of deaths/number at risk | 245/1243 | |
Clinical risk factors | ||
Mechanical ventilation (0, 1) | 0.84 (0.65, 1.09) | 0.20 |
Sepsis (0, 1) | 0.99 (0.74, 1.32) | 0.92 |
Charlson Comorbidity Index (+ 1 point) | 1.24 (1.16, 1.32) | < 0.0001 |
SOFA score (+ 1 point) | 0.99 (0.86, 1.15) | 0.92 |
Length of ICU stay (+ 1 day) | 1.18 (1.03, 1.34) | 0.014 |
Circulating biomarkers | ||
BNP (+ 1 SD) | 1.38 (1.19, 1.60) | < 0.0001 |
hsTNT (+ 1 SD) | 1.19 (1.03, 1.39) | 0.022 |
hsTnI (+ 1 SD) | 1.14 (0.99, 1.32) | 0.076 |
ADM (+ 1 SD) | 1.39 (1.11, 1.48) | 0.0006 |
sST2 (+ 1 SD) | 1.09 (0.94, 1.25) | 0.23 |
NGAL (+ 1 SD) | 1.28 (1.11, 1.47) | 0.0005 |
Urinary biomarkers | ||
Albuminuria (+ 1 SD) | 1.23 (1.07, 1.42) | 0.0046 |
NGAL (+ 1 SD) | 1.13 (0.98, 1.31) | 0.094 |
ACM128 (+ 1 SD) | 2.41 (2.00, 2.91) | < 0.0001 |