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Table 4 Clinical features of patients receiving AIT on admission or delayed AIT

From: Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study

 Missing dataPatients receiving AIT from day 0 n = 340Patients receiving AIT between day > 0 and day 30 n = 226p value
Male, n (%)0/4227 (68)147 (65)NS
Age, years, median [IQR]1/159 [49–73]58 [47–70]NS
Clinical presentation on day 0
 Delay pain/ICU admission, days, median [IQR]04 [1–11]2 [1–5]< 0.001
 Oliguria/anuria, n (%)0151 (44)99 (44)NS
 BISAP score, median [IQR]4/142 [1–2]1 [0–2]< 0.001
 Balthazar score grade E, n (%)0196 (58)155 (69)< 0.05
Severity criteria on day 0
 SOFA score, median [IQR]1/115 [3–7]4 [3–6]< 0.05
 Respiratory failure*, n (%)0129 (38)68 (30)NS
 Cardiovascular failure*, n (%)0157 (46)40 (18)< 0.001
 Renal failure*, n (%)065 (19)51 (23)NS
 Septic shock, n (%)0106 (31)4 (2)< 0.001
 Acute respiratory distress syndrome, n (%)036 (11)16 (7)NS
Therapeutic management on day 0
 Vasoactive support, n (%)0/1160 (47)42 (19)< 0.001
 Mechanical ventilation, n (%)0/4126 (38)57 (25)< 0.01
 Fluid loading, n (%)1/9270 (82)169 (75)NS
 Renal replacement therapy, n (%)1/740 (12)20 (9)NS
Main treatments between day > 0 and day 30
 Need for red blood cells transfusion, n (%)0113 (33)78 (35)NS
 Duration of mechanical ventilation, days, median [IQR]2/83 [0–11]9 [0–21]< 0.001
 Vasoactive support, n (%)0/1205 (60)126 (56)NS
 Renal replacement therapy, n (%)1/091 (27)85 (38)< 0.01
 Duration of RRT, days, median [IQR]5/65 [2–15]10 [3–16]NS
 Duration of AIT, days, median [IQR]13/115 [2–12]7 [3–14]< 0.01
Main complications between day > 0 and day 30
 Acute respiratory distress syndrome, n (%)0/2100 (30)101 (45)< 0.001
 Septic shock, n (%)16/30123 (40)85 (40)NS
 Pancreatic necrosis, n (%)2/16211 (65)174 (78)< 0.01
 Infected necrosis, n (%)6/22113 (36)83 (38)NS
 Gastro-intestinal perforation, n (%)9/2128 (9)22 (10)NS
 Vascular thrombosis, n (%)5/2050 (16)33 (15)NS
 Acute mesenteric ischaemia, n (%)7/2035 (11)27 (12)NS
 Intra-abdominal collection, n (%)5/16147 (45)89 (40)NS
 Abdominal compartment syndrome, n (%)4/2130 (9)35 (16)< 0.05
 Haemorrhage, n (%)6/2046 (14)33 (15)NS
 Peritonitis, n (%)8/2258 (18)25 (11)< 0.05
 Cholangitis, n (%)7/1841 (13)16 (7)< 0.05
 Digestive fistula, n (%)8/2021 (7)9 (4)NS
Clinical management between day > 0 and day 30
 Endoscopic necrosectomy, n (%)2/483 (25)64 (29)NS
 Surgical necrosectomy, n (%)2/4131 (39)86 (38)NS
 Radiological drainage, n (%)2/472 (21)47 (21)NS
 Duration of ICU stay, days, median [IQR]08 [3–22]17 [7–34]< 0.001
 ICU readmission, n (%)0/127 (8)23 (10)NS
 Hospital mortality rate, n (%)091 (27)50 (22)NS
 Time to death, days, median [IQR]08 [1–31]17 [5–38]< 0.05
  1. NS non-significant, ERCP endoscopic retrograde cholangiopancreatography
  2. *According to the definition of the SOFA score