Table 2 Occurrence of CHX-induced mucositis and its association with direct causes of death and temporal outcomes reported during ICU stay

Outcome

Without mucositis % (n/N)

With CHX-induced mucositis % (n/N)

RR (95%CI)

 Death, in general

27.5 (65/236)

66.7 (12/18)

2.42 (1.64–3.56)

 Death due to any infection

20.3 (48/236)

44.4 (8/18)

2.18 (1.23–3.88)

 Death due to respiratory infection

10.6 (25/236)

22.2 (4/18)

2.10 (0.82–5.37)

 Death due to intrabdominal infection

5.93 (14/236)

16.7 (3/18)

2.81 (0.89–8.88)

 Death due to acute respiratory failure

3.4 (8/236)

5.6 (1/18)

1.64 (0.22–12.39)

 Death due to cardiovascular events

2.5 (6/236)

0 (0/18)

0

Temporal outcome

Without CHX-induced mucositis

Median (interquartile range)

With CHX-induced mucositis

Median (interquartile range)

p value^a

 Duration of mechanical ventilation (days)

7 (3–16)

13 (8–20)

0.023

 Duration of antimicrobial therapy (days)

5 (2–11)

12.5 (8–18)

0.002

 Length of stay in the ICU (days)

7 (4–15)

14 (9–20)

0.003