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Table 1 Clinical and demographic characteristics of patients and occurrence of adverse events related to oral care procedures evaluated as potential risk factors for death during ICU stay

From: Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial

Clinical and demographic characteristics

Discharged alive

Death in the ICU

Crude RR (95%CI)

Adjusted OR (95%CI)

Adjusted p value

Female

69.4 (84/121)

30.6 (37/121)

Male

69.9 (93/133)

30.1 (40/133)

0.98 (0.68–1.43)

0.83 (0.45–1.52)

0.553

Age in years

57 (41–71)

62 (52–71)

1.02 (1.00–1.03)

1.00 (0.98–1.02)

0.781

APACHE II score

20 (16–26)

27 (21–31)

1.10 (1.06–1.15)

1.10 (1.05–1.15)

< 0.001

Routine oral care

68.5 (87/127)

31.5 (40/127)

Dental treatment

70.9 (90/127)

29.1 (37/127)

0.92 (0.64–1.34)

0.92 (0.50–1.67)

0.779

Without adverse events related to oral care

73.4 (168/229)

26.6 (61/229)

With any adverse event related to oral care

36.0 (9/25)

64.0 (16/25)

2.40 (1.67–3.46)

5.46 (2.11–14.13)

< 0.001

Without CHX-induced mucositis

72.5 (171/236)

27.5 (65/236)

With CHX-induced mucositis

33.3 (6/18)

66.7 (12/18)

2.42 (1.64–3.56)

6.14 (1.98–19.08)

0.002

Without intraoral bleeding

71 (174/245)

29 (71/245)

With intraoral bleeding

33.3 (3/9)

66.7 (6/9)

2.30 (1.40–3.80)

3.74 (0.75–18.58)

0.106

  1. Values expressed are % (n/N) of patients for categorical variables and median (interquartile range) for continuous variables
  2. ICU intensive care unit, APACHE II Acute Physiology and Chronic Health Evaluation System II, RR relative risk, OR odds ratio