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Table 2 Comparison of key clinical characteristics across phenotypes in subset of mice for biomarker measurement (N = 73)

From: Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids

Characteristic

All mice

Class 1

Class 2

p valueb

No.

73

64

9

 

Time to deterioration [h]: mean (SD)

7.5 (1.2)

7.7 (1.0)

5.6 (0.9)

< 0.001

Heart rate 5 h after CLP [bpm]: mean (SD)

574 (59)

586 (46)

461 (46)

< 0.001

Temperature 5 h after CLP [°C]: mean (SD)

31.7 (1.5)

32.0 (1.3)

29.3 (1.2)

< 0.001

Heart rate 7 h after CLPa [bpm]: mean (SD)

566 (45)

568 (42)

438 (−)

0.003

Temperature 7 h after CLPa [°C]: mean (SD)

31.7 (1.1)

31.7 (1.0)

29 (−)

< 0.001

  1. Abbreviations: No. number, SD standard deviation, CLP cecal ligation and puncture, bpm beats per minute
  2. aOnly 1 mouse with clinical data available at 7 h after CLP
  3. bp value compares class 1 to class 2 using analysis of variance (ANOVA)
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Critical Care

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