Table 2 Ventilatory parameters at the initiation of mechanical ventilation among mechanically ventilated participants who had ARDS at mechanical ventilation onset, those who developed ARDS after mechanical ventilation onset, and those who never developed ARDS
Variables, mean (SD) | Overall, n = 1657 | ARDS at mechanical ventilation onset, n = 334 | ARDS after mechanical ventilation onset, n = 180 | No ARDS, n = 1143 | p value |
|---|---|---|---|---|---|
FiO2 | 0.47 (0.18) | 0.54 (0.19) | 0.44 (0.15) | 0.45 (0.18) | < 0.001 |
PEEP, cm H2O | 7.7 (3.7) | 10.1 (4.5) | 7.5 (3.4) | 7.0 (3.2) | < 0.001 |
PaO2/FiO2, mmHg | 260.3 (125.7) | 201.6 (101.5) | 262.4 (135.0) | 278.2 (125.5) | < 0.001 |
Tidal volume, mL | 470.9 (98.9) | 479.2 (108.7) | 468.4 (93.0) | 468.9 (96.7) | 0.23 |
Tidal volume, mL/kg PBW | 8.5 (2.2) | 8.7 (2.3) | 8.6 (2.1) | 8.5 (2.2) | 0.16 |
Static compliance, mL/cm H2O | 34.8 (23.9) | 33.9 (20.4) | 34.7 (22.1) | 35.1 (25.2) | 0.79 |
Driving pressure, cm H2O | 16.4 (5.4) | 17.4 (5.8) | 16.4 (5.3) | 16.1 (5.2) | < 0.01 |
Mean airway pressure, cm H2O | 12.6 (4.2) | 15.2 (4.6) | 12.6 (4.0) | 11.9 (3.8) | < 0.001 |
Peak inspiratory pressure, cm H2O | 25.1 (6.7) | 29.2 (7.0) | 25.4 (6.7) | 23.9 (6.1) | < 0.001 |
Plateau pressure, cm H2O | 24.0 (6.7) | 27.2 (7.5) | 23.5 (6.0) | 23.1 (6.3) | < 0.001 |