Table 2 Clinical and laboratory parameters at baseline

Time from ICU admission to CRRT start, day

4.4 ± 7.7

4.3 ± 7.6

4.4 ± 7.7

0.54

SBP, mmHg

114.1 ± 22.8

118.9 ± 24.0

111.0 ± 21.5

0.007

DBP, mmHg

65.8 ± 16.0

67.7 ± 15.7

64.6 ± 16.1

0.13

MAP, mmHg

81.9 ± 15.9

84.8 ± 15.6

80.1 ± 15.9

0.02

Vasopressor use, n (%)

179 (69.4)

55 (54.5)

124 (79.0)

< 0.001

 Dose (NE, μg/kg/min)

0.59 [0.26–1.66]

0.50 [0.15–1.13]

0.65 [0.31–1.76]

0.06

0.98

 0.9% sodium chloride

62 (25.7)

25 (27.2)

37 (24.8)

 0.45% sodium chloride

18 (7.5)

7 (7.6)

11 (7.4)

 Dextrose

113 (46.9)

42 (45.7)

71 (47.7)

 Plasma solution

25 (10.4)

6 (6.5)

19 (12.8)

 Lactate Ringer’s solution

23 (9.5)

12 (13.0)

11 (7.4)

Replacement of 20% albumin, n (%)

156 (60.7)

56 (56.0)

100 (63.7)

0.16

Enteral nutritional fluid, n (%)

28 (10.9)

19 (19.0)

9 (5.8)

0.001

 Duration of CRRT, h

5.4 ± 6.4

7.2 ± 7.8

4.3 ± 4.9

< 0.001

 Target clearance (mL/kg/h)

36.7 [34.2–40.9]

36.8 [34.1–41.5]

36.6 [34.2–39.9]

0.24

 Dialysate flow rate, mL/h

1033.5 ± 164.5

1031.2 ± 181.9

1034.9 ± 152.8

0.86

 Replacement flow rate, mL/h

1211.1 ± 389.9

1258.9 ± 422.9

1180.1 ± 380.8

0.12

 Blood flow rate, mL/min

113.6 ± 33.0

116.5 ± 33.4

11.7 ± 32.8

0.25

 Anticoagulation use, n (%)

159 (61.6)

(66 (65.3)

93 (59.2)

0.19

 Creatinine, mg/dL

1.4 ± 0.5

1.4 ± 0.5

1.4 ± 0.4

0.95

 eGFR, mL/min/1.73m²

22.0 ± 16.5

21.3 ± 17.3

22.4 ± 16.1

0.62

 White blood cells, n/μL

13.1 ± 10.4

11.8 ± 6.0

14.0 ± 12.4

0.10

 Hemoglobin, g/dL

9.4 ± 2.2

9.3 ± 1.9

9.5 ± 2.3

0.59

 Platelets, × 10³/μL

126.8 ± 87.9

141.9 ± 91.3

117.0 ± 84.5

0.03

 PT-INR

2.0 ± 3.7

1.6 ± 0.6

2.3 ± 4.7

0.14

 Total bilirubin, mg/dL

2.9 ± 5.2

1.7 ± 3.3

3.7 ± 6.0

0.007

 Aspartate aminotransferase, IU/L

362.5 ± 66.5

481.7 ± 140.8

285.1 ± 60.3

0.15

 Alanine aminotransferase, IU/L

152.7 ± 30.8

209.0 ± 71.3

115.9 ± 20.4

0.14

 Lactic acid, mg/dL

58.6 ± 5.4

57.6 ± 9.5

59.2 ± 6.5

0.89