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Table 5 Myeloid cell effect of specific MDSC miRNAs

From: Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

miRNA

Day 4

Day 14

Function

hsa-miR-21-5p

↑

↓

Expressed in myeloid cells. Elevated levels enhance proliferation and block myeloid differentiation (Zhang et al. 2014. JI)

hsa-miR-17-5p

↑

↓

Plays an important role in regulating the suppressive potential of MDSCs via STAT3 (Zhang et al. 2011. JI)

hsa-miR-181a-5p

↑

↓

Expressed in myeloid cells. Elevated levels are known to induce MDSC proliferation (McClure et al. 2014. ASM)

hsa-miR-106a-5p

↑

↓

Influences myeloid development. Overexpression represses M-CSFR and limits myeloid differentiation (El-Gazzar et al. 2013. Innate Immunity)

  1. The myeloid cell effects of the specific MDSC miRNAs that were found to have different expression patterns in MDSCs from septic patients at says 4 and 14 after initial infection
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Critical Care

ISSN: 1364-8535