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Table 4 Gas exchange at different levels of PEEP in patients with and without intrinsic PEEP

From: Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients

ParameterPatients with intrinsic PEEP (n = 87)Patients without intrinsic PEEP (n = 130)PPEEPiPPEEPPPEEPix PEEP
PaO2 (mmHg)0.761< 0.0010.939
 5 cmH2O71 [64–83]73 [63–93]   
 15 cmH2O94 [75–124]99 [80–123]
PaO2/FiO20.118< 0.0010.957
 5 cmH2O138 [100–183]151 [119–185]   
 15 cmH2O194 [144–252]200 [159–259]
PaCO2 (mmHg)0.1110.5180.787
 5 cmH2O44 [40–52]44 [38–51]   
 15 cmH2O44 [41–52]38 [22–42]
Alveolar dead space (%)0.2790.3450.425
 5 cmH2O20 [12–26]23 [13–30]   
 15 cmH2O19 [13–27]21 [11–29]
Alveolar dead space (mL)0.1860.0100.107
 5 cmH2O105 [66–137]111 [74–153]   
 15 cmH2O98 [68–131]105 [62–140]   
  1. Data are expressed as median [I.Q. range] as appropriate
  2. Two-way repeated measures analysis of variance (ANOVA) followed by all pairwise multiple comparison procedures (Holm-Sidak method) was used for analysis
  3. p < 0.05 raising end-expiratory pressure from 5 to 15 cmH2O
  4. There are no significant interactions
  5. n sample size, PEEP positive end-expiratory pressure
  6. Italics: for all the statistical data
  7. Bold italics: for statistical significant data