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Table 2 Regression analysis for mortality at 28 days for CytoSorb-treated patients

From: Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: a propensity-score-weighted retrospective study

Variables

Univariable

 

Full multivariable model (forced)

 

Final multivariable model (bstep LR)

 

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Age per 10 years older

1.99 (1.3–3.1)

0.002

1.64 (1.0–2.7)

0.050

1.67 (1.0–2.7)

0.034

Female gender

1.50 (0.6–4.0)

0.412

–

 

–

 

Body mass index

0.96 (0.9–1.0)

0.260

–

 

–

 

SOFA admission

1.20 (1.0–1.4)

0.041

–

 

–

 

SOFA at the start of treatment

1.28 (1.1–1.6)

0.014

1.10 (0.8–1.4)

0.505

–

 

MAP admission

0.99 (0.9–1.0)

0.460

–

 

–

 

MAP at the start of treatment

0.96 (0.9–1.0)

0.051

0.99 (1.0–1.03)

0.739

–

 

Lactate admission

1.07 (0.9–1.2)

0.180

–

 

–

 

Lactate at the start of treatment

1.16 (1.0–1.3)

0.014

1.13 (1.0–1.3)

0.108

1.15 (1.0–1.3)

0.031

Noradrenaline admission

2.25 (0.8–6.0)

0.106

–

 

–

 

Noradrenaline treatment

2.60 (1.2–5.9)

0.021

0.98 (0.3–2.8)

0.973

–

 

Noradrenaline duration

1.02 (0.9–1.2)

0.731

–

 

–

 

Admission ICU to treatment

0.88 (0.7–1.1)

0.216

–

 

–

 

Admission hospital to treatment

0.98 (0.9–1.1)

0.675

–

 

–

 

Surgery

0.37 (0.1–1.0)

0.055

0.43 (0.1–1.6)

0.206

–

 

Type of sepsis:

–

 

–

 

–

 

 Pneumosepsis

3.52 (1.0–12.7)

0.054

2.83 (0.5–16.9)

0.254

5.47 (1.2–25.2)

0.029

 Abdominal sepsis

0.51 (0.2–1.3)

0.171

–

 

–

 

 Cutaneous sepsis

0.27 (0.1–1.4)

0.117

–

 

–

 

 Vascular sepsis

4.86 (0.5–46.0)

0.168

–

 

–

 

 Sepsis unknown cause

2.36 (0.4–13.8)

0.343

–

 

–

 

History of:

–

 

–

 

–

 

 Diabetes mellitus

1.61 (0.5–5.3)

0.432

–

 

–

 

 Hypertension

1.31 (0.5–3.6)

0.601

–

 

–

 

 COPD

1.97 (0.4–9.0)

0.380

    

 Coronary artery disease

0.86 (0.2–3.5)

0.831

–

 

–

 

 Heart failure

NA

0.999

    

 Chronic kidney disease

1.98 (0.4–9.0)

0.380

–

 

–

 

 Hemodialysis/peritoneal

1.10 (0.1–18.3)

0.949

–

 

–

 

 CVA

1.10 (0.2–5.9)

0.908

–

 

–

 

 Peripheral artery disease

2.99 (0.7–12.7)

0.139

–

 

–

 
  1. MAP mean arterial pressure, ICU intensive care unit, COPD chronic obstructive pulmonary disease, CVA cerebrovascular accident
  2. Statistically significant data are italicized
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