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Table 2 QUADAS-2 score assessment of the included studies

From: Functional hemodynamic tests: a systematic review and a metanalysis on the reliability of the end-expiratory occlusion test and of the mini-fluid challenge in predicting fluid responsiveness

StudiesPatient selectionIndex testReference standardFlow and timingFinal scoreFinal risk
Risk of biasApplicability judgmentsTOTRisk of biasApplicability judgmentsTOTRisk of biasApplicability judgmentsTOT
Operating roomGuinot et al. [33]High3Low14Low1Low12Low1Low12Low19L
Biais et al. [34]High3Low14Low1Low12Low1Low13Low110M
Biais et al. [35]Unclear2Low13Low1Low12Low1Low12Low18L
Guinot et al. [36]Unclear2High35Low1Low12High3Low14Low112H
Preisman et al. [37]High3High36Low1Low12Low1Low12Low111H
Biais et al. [38]High3Low14Low1Low12Low1Low12High311H
De Broca et al. [39]Unclear2Low13Low1Low12Low1Low12Low18L
Intensive care unitWu et al. [40]Smorenberg et al. [41]UncleaR2Low13Low1Low12Low1Low12Low18L
Low1High34Low1Low12Low1Low12High311H
Muller et al. [29]Unclear2Low13Low1Low12Low1Low12Low18L
Monge Garcia et al. [42]Low1Unclear23Low1Unclear23High3Low14High313H
Perel et al. [28]High3Low14Low1Low12Low1Low12High311H
Yonis et al. [43]Unclear2High35Unclear2Low13Low1Low12Low111H
Xiao-ting et al. [44]Unclear2Low13Low1Low12Low1Low12High310H
Mallat et al. [45]High3Low14Low1Low12Low1Low12Low19M
Georges et al. [46]High3Low14Low1Low12Low1Low12Low19M
Wilkman et al. [47]High3Low14Low1Low12Low1Low12High311H
Jozwiak et al. [48]Unclear2Low13Low1Low12Low1Low12Low18L
Monnet et al. [23]High3Low14Low1Low12Low1Low12Low19M
Myatra et al. [49]Unclear2Low13Low1Low12Low1Low12Low18L
Monnet et al. [50]Unclear2Low13Low1Low12Low1Low12Low18L
  1. For each study, the risk of bias is calculated as the sum of the four categories; we calculated the sum of these points. L = studies showing a score below the median of the sums of all studies. H = studies showing a score above the median of the sums of all studies. M = studies showing a score equal to the median of the sums of all studies