|
Number of participants (n (%))
|
10
|
30
|
–
|
|
Female sex (n (%))
|
5 (50)
|
7 (23)
|
0.11
|
|
Age (years, median (IQR))
|
30 (27–34)
|
67 (58–80)
|
< 0.0001
|
|
BMI (kg/m2, median (IQR))
|
23.6 (21.3–26.1)
|
25.3 (21.7–28.2)
|
0.34
|
|
Duration of sepsis at study inclusion (days, median (IQR))*
|
–
|
2 (1–5)
|
–
|
|
SOFA score (median (IQR))
|
–
|
9 (5–12)
|
–
|
|
Organ replacement therapy (n (%))
|
–
|
18 (60)
|
–
|
|
Mechanical ventilation (n (%))
|
–
|
17 (56.7)
|
–
|
|
Acute dialysis (n (%))
|
–
|
5 (16.7)
|
–
|
|
Vasopressors (n (%))
|
–
|
20 (66.7)
|
–
|
|
Norepinephrine dose (μg/kg/min)
|
–
|
0.05 (0–0.16)
|
–
|
|
Septic shock (n (%))**
|
–
|
3 (10)
|
–
|
|
Hospital mortality (n (%))
|
–
|
10 (33.3)
|
–
|
|
CCI score (median (IQR))
|
–
|
1.5 (0.8–2.3)
|
–
|
|
Comorbidities (n (%))
|
|
Chronic respiratory disease
|
–
|
8 (26.7)
|
–
|
|
Congestive heart failure
|
–
|
16 (53.3)
|
–
|
|
Chronic hepatic disease
|
–
|
3 (10)
|
–
|
|
Dialysis-dependent CKD
|
–
|
1 (3.3)
|
–
|
|
Malignancy
|
–
|
5 (16.7)
|
–
|
|
Diabetes mellitus
|
–
|
5 (16.7)
|
–
|
|
Focus of infection (n (%))
|
|
Respiratory tract
|
–
|
17 (56.7)
|
–
|
|
Prosthesis
|
–
|
4 (13.3)
|
–
|
|
Gastrointestinal tract
|
–
|
3 (10)
|
–
|
|
Unknown
|
–
|
2 (6.7)
|
–
|
|
Skin
|
–
|
2 (6.7)
|
–
|
|
Urinary tract
|
–
|
1 (3.3)
|
–
|
|
Heart
|
–
|
1 (3.3)
|
–
|
|
Endothelial glycocalyx (median (IQR))
|
|
PBR 5–25 (μm)
|
2.04 (1.97–2.10)
|
2.34 (2.21–2.46)
|
< 0.0001
|
|
Syndecan-1 (ng/ml)
|
21.3 (13.2–56.7)
|
204.5 (114.2–358.9)
|
< 0.0001
|
|
Microcirculation data (median (IQR))
|
|
TVD (mm/mm2)
|
18.88 (17.56–21.68)
|
19.17 (17.06–20.24)
|
0.87
|
|
PVD (mm/mm2)
|
18.54 (17.19–21.26)
|
16.97 (14.96–19.87)
|
0.08
|
|
PPV (%)
|
98.73 (96.55–99.80)
|
92.58 (85.63–97.14)
|
0.0004
|
|
MFI (points)
|
2.93 (2.89–2.96)
|
2.74 (2.58–2.91)
|
0.002
|
|
HI (%)
|
0.04 (0.01–0.06)
|
0.08 (0.03–0.16)
|
0.04
|
|
Macrocirculation data (median (IQR))
|
|
MAP (mmHg)
|
94.2 (85.4–102.4)
|
73.0 (67.5–84.6)
|
0.0001
|
|
Heart rate (pulse/min)
|
73 (65–83)
|
91 (81–101)
|
0.0004
|
|
Respiratory rate (breaths/min)
|
14 (13–15)
|
20 (17–26)
|
< 0.0001
|
|
Temperature (°C)
|
36.6 (36.5–36.8)
|
37 (36.4–37.7)
|
0.12
|
|
Laboratory data (median (IQR))
|
|
CRP (mg/dl)
|
0.5
|
23.2 (16.9–33.3)
|
< 0.0001
|
|
IL-6 (ng/ml)
|
2.0 (2.0–2.5)
|
367.0 (96.0–1121.0)
|
< 0.0001
|
|
PCT (ng/ml)
|
0.04 (0.03–0.05)
|
9.08 (1.24–48.23)
|
< 0.0001
|
|
pH
|
–
|
7.42 (7.36–7.48)
|
–
|
|
Lactate (mmol/l)
|
0.90 (0.65–1.20)
|
1.70 (0.98–2.00)
|
0.001
|
|
Albumin (g/dl)
|
4.8 (4.5–5.0)
|
2.5 (2.0–3.0)
|
< 0.0001
|
|
Total serum protein (g/dl)
|
7.1 (6.8–7.5)
|
5.5 (5.1–6.0)
|
< 0.0001
|
