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Table 1 A summary of recent meta-analysis of vitamin C administration in critical care patients

From: Vitamin C administration in the critically ill: a summary of recent meta-analyses

Publication detailsTitleSelection criteria (PICO)Included studiesSubgroup analysisFindings
Putzu et al. [3]Crit Care MedThe effect of vitamin C on clinical outcome in critically ill patients: A systematic review with meta-analysis of randomised controlled trialsP—adult critically ill patientsI—vitC (any regimen)C—placebo or no therapyO—mortality, acute kidney injury, supraventricular arrhythmia, ventricular arrhythmia, stroke, ICU LOS, hospital LOS44 RCTs:16 in ICU setting (n = 2857)28 in cardiac surgery (n = 3598)Mixed ICU vs burns vs sepsis/septic shock vs acute pancreatitisVitC alone vs enteral vitC vs IV vitC vs IV vitC > 5 gICU patients:X mortalityX acute kidney injuryX ICU or hospital LOSCardiac surgery:↓ postoperative atrial fibrillation↓ ICU and hospital LOS
Wang et al. [4]Ann Intensive CareEffects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysisP—critically ill patientsI—IV vitC (including co-administration of antioxidants)C—placebo or no interventionO—mortality, resuscitation fluid requirement, urine output, acute kidney injury, vasopressor requirement, duration of mechanical ventilation, ICU and/or hospital LOS12 RCT, quasi-RCT, observational (n = 1210)Low dose vs medium dose vs high doseBurn vs sepsis vs others↓ mortality (doses of 3–10 g/day)X morality (< 3 g/day or ≥ 10 g/day)↓ duration of vasopressor support↓ duration of mechanical ventilationX acute kidney injuryX ICU or hospital LOSX fluid requirementX urine output
Hemila and Chalker [5]Vitamin C can shorten the length of stay in the ICU: A meta-analysisP—ICU patientsI—vitCC—placebo or noneO—ICU LOS, duration of mechanical ventilation18 controlled trials (n = 2004)including 13 cardiac surgeryIV vs oral1–2 days ICU vs 3–5 days ICU> 24 h ventilation vs < 24 h ventilation↓ ICU LOS↓ duration of mechanical ventilation
Langlois et al. [6]JPENVitamin C supplementation in the critically ill: A systematic review and meta-analysisP—ICU patientsI—vitC (enteral or parenteral)C—placebo or noneO—mortality, incident infections, ICU LOS, hospital LOS, duration of mechanical ventilation11 RCTs9 RCTs with mortality (n = 1322)Low dose vs high doseCombined therapy vs monotherapyOral/enteral vs parenteralNon-septic vs septicHigher-quality trials vs low-quality trialsX mortality↓ (trend) mortality (IV high dose vitC monotherapy)X infectionsX ICU or hospital LOSX duration of mechanical ventilation
Zhang and Jativa [7]SAGE Open MedVitamin C supplementation in the critically ill: A systematic review and meta-analysisP—critically ill adult patientsI—IV vitCC—placebo or no interventionO—mortality, duration of mechanical ventilation, duration of vasopressor support, fluid requirements, urine output4 RCTs and 1 retrospective (n = 142) X mortality↓ need for vasopressor support↓ duration of mechanical ventilation↓ (trend) fluid requirements↑ (trend) urine output
LiCrit Care [1]Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsisP—patients with sepsisI—IV vitCC—placebo or noneO—mortality, ICU LOS, vasopressor duration2 RCTs and 1 before-after ↓ mortalityX ICU LOS↓ vasopressor duration
Lin et al. [8]Open J Intern MedAdjuvant administration of vitamin C improves mortality of patients with sepsis and septic shock: A systems review and meta-analysisP—patients with septic shock and severe sepsisI—vitCC—placeboO—mortality4 RCTs and 2 retrospective studies (n = 109)RCT vs retrospectiveHigh dose vs low doseX mortality↓ mortality (doses of > 50 mg/kg/day)X ICU LOS
  1. ICU intensive care unit, IV intravenous, LOS length of stay, PICO patients, intervention, comparator, outcome, RCT randomized controlled trial, vitC vitamin C