Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Table 2 Associations of circulating heparan sulfate with plasma indices of endothelial injury, coagulation, and inflammation (ProCESS cohort, 6 h after enrollment)

Marker	Pearson r	p-value	Number of subjects analyzed
Endothelial Injury/Activation
sFLT-1 (soluble VEGF-receptor 1)	0.4097	0.0017	56
Angiopoietin-2	0.2367	0.0790	56
Inflammation
Tumor necrosis factor-α	0.2325	0.1384	42
Interleukin-6	0.3537	0.0216	42
Coagulation
Tissue plasminogen activator	0.3356	0.0114	56
D-dimer	0.0926	0.5699	40
Thrombomodulin	0.4997	<0.0001	56
Other
Lactate	-0.0765	0.6527	37

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