Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Table 4 Multivariable linear regression model for an association between 24-h NT-proBNP levels and physical performance on the SPPB at 6 and 12 months after sepsis

Effect	Estimate	SE	p
6-month SPPB
Intercept	11.28	2.10	< 0.0001
NT-proBNP (lowest tertile as reference)			0.0118^†
Middle tertile	1.25	1.11	0.2596
Highest tertile	− 2.24	1.50	0.1378
Sex (female)	− 1.51	0.93	0.1069
Race (non-Caucasian)	− 0.62	1.38	0.6512
Charlson comorbidity index	− 0.61	0.19	0.0014
Age	− 0.03	0.04	0.4986
CCI^‡	− 3.32	1.06	0.0023
APACHE	0.03	0.06	0.6476
12-month SPPB
Intercept	12.89	1.66	< 0.0001
NT-proBNP (lowest tertile as reference)			0.0060^†
Middle tertile	0.02	0.90	0.9825
Highest tertile	− 2.92	1.20	0.0165
Sex (female)	− 2.79	0.71	0.0002
Race (non-Caucasian)	− 1.01	1.07	0.3487
Charlson comorbidity index	− 0.75	0.12	< 0.0001
Age	− 0.009	0.04	0.8206
CCI^‡	− 4.33	0.88	< 0.0001
APACHE	0.04	0.04	0.3579

Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
SPPB short physical performance battery, SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
^†Overall p value
^‡Rapid recovery (RAP) patients as a reference group

ISSN: 1364-8535