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Table 4 Multivariable linear regression model for an association between 24-h NT-proBNP levels and physical performance on the SPPB at 6 and 12 months after sepsis

From: Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Effect

Estimate

SE

p

6-month SPPB

 Intercept

11.28

2.10

< 0.0001

 NT-proBNP (lowest tertile as reference)

  

0.0118

  Middle tertile

1.25

1.11

0.2596

  Highest tertile

− 2.24

1.50

0.1378

 Sex (female)

− 1.51

0.93

0.1069

 Race (non-Caucasian)

− 0.62

1.38

0.6512

 Charlson comorbidity index

− 0.61

0.19

0.0014

 Age

− 0.03

0.04

0.4986

 CCI

− 3.32

1.06

0.0023

 APACHE

0.03

0.06

0.6476

12-month SPPB

 Intercept

12.89

1.66

< 0.0001

 NT-proBNP (lowest tertile as reference)

  

0.0060

  Middle tertile

0.02

0.90

0.9825

  Highest tertile

− 2.92

1.20

0.0165

 Sex (female)

− 2.79

0.71

0.0002

 Race (non-Caucasian)

− 1.01

1.07

0.3487

 Charlson comorbidity index

− 0.75

0.12

< 0.0001

 Age

− 0.009

0.04

0.8206

 CCI

− 4.33

0.88

< 0.0001

 APACHE

0.04

0.04

0.3579

  1. Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
  2. SPPB short physical performance battery, SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
  3. Overall p value
  4. Rapid recovery (RAP) patients as a reference group