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Table 4 Multivariable linear regression model for an association between 24-h NT-proBNP levels and physical performance on the SPPB at 6 and 12 months after sepsis

From: Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

6-month SPPB
 Intercept11.282.10< 0.0001
 NT-proBNP (lowest tertile as reference)  0.0118
  Middle tertile1.251.110.2596
  Highest tertile− 2.241.500.1378
 Sex (female)− 1.510.930.1069
 Race (non-Caucasian)− 0.621.380.6512
 Charlson comorbidity index− 0.610.190.0014
 CCI− 3.321.060.0023
12-month SPPB
 Intercept12.891.66< 0.0001
 NT-proBNP (lowest tertile as reference)  0.0060
  Middle tertile0.020.900.9825
  Highest tertile− 2.921.200.0165
 Sex (female)− 2.790.710.0002
 Race (non-Caucasian)−
 Charlson comorbidity index− 0.750.12< 0.0001
 Age− 0.0090.040.8206
 CCI− 4.330.88< 0.0001
  1. Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
  2. SPPB short physical performance battery, SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
  3. Overall p value
  4. Rapid recovery (RAP) patients as a reference group