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Table 4 Multivariable linear regression model for an association between 24-h NT-proBNP levels and physical performance on the SPPB at 6 and 12 months after sepsis

From: Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Effect Estimate SE p
6-month SPPB
 Intercept 11.28 2.10 < 0.0001
 NT-proBNP (lowest tertile as reference)    0.0118
  Middle tertile 1.25 1.11 0.2596
  Highest tertile − 2.24 1.50 0.1378
 Sex (female) − 1.51 0.93 0.1069
 Race (non-Caucasian) − 0.62 1.38 0.6512
 Charlson comorbidity index − 0.61 0.19 0.0014
 Age − 0.03 0.04 0.4986
 CCI − 3.32 1.06 0.0023
 APACHE 0.03 0.06 0.6476
12-month SPPB
 Intercept 12.89 1.66 < 0.0001
 NT-proBNP (lowest tertile as reference)    0.0060
  Middle tertile 0.02 0.90 0.9825
  Highest tertile − 2.92 1.20 0.0165
 Sex (female) − 2.79 0.71 0.0002
 Race (non-Caucasian) − 1.01 1.07 0.3487
 Charlson comorbidity index − 0.75 0.12 < 0.0001
 Age − 0.009 0.04 0.8206
 CCI − 4.33 0.88 < 0.0001
 APACHE 0.04 0.04 0.3579
  1. Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
  2. SPPB short physical performance battery, SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
  3. Overall p value
  4. Rapid recovery (RAP) patients as a reference group