Table 1 Characteristics of 259 critically ill patients with sepsis or septic shock
Demographic data | N (%) or Median [IQR] | |
Age, year | 68 [57–80] | |
Male sex | 133 (51) | |
Body-mass index, kg/m2 | 25 [22–28] | |
SAPS II score, points | 54 [41–70] | |
SOFA score at day 1, points | 10 [5–14] | |
Pre-existing conditions | ||
Atherosclerotic disease | 67 (26) | |
Cirrhosis | 27 (12) | |
Sepsis origin | ||
Community-acquired pneumonia | 113 (44) | |
Intra-abdominal | 65 (26) | |
Urinary tract | 28 (11) | |
Skin and soft tissue | 21 (8) | |
Others | 27 (11) | |
Clinical parameters | At H0 | At H6 |
Heart rate, beats/min | 105 [89–121] | 100 [85–118] |
Mean arterial pressure, mm Hg | 71 [63–80] | 73 [67–82] |
Cardiac index, l/min/m2 | 4.9 [3.9–6.2] | 5.0 [3.9–6.03] |
Urinary output, ml/kg/h | – | 0.46 [0.13–0.90] |
Arterial lactate, mmol/l | 2.8 [1.5–5.6] | 2.4 [1.4–5.3] |
Mottling score | ||
0 | 109 (42) | 125 (49) |
1 | 22 (8) | 36 (14) |
2 | 51 (20) | 29 (11) |
3 | 41 (16) | 29 (11) |
4 | 16 (6) | 14 (5) |
5 | 20 (8) | 24 (9) |
Drugs | ||
Norepinephrine | 156 (60) | 188 (73) |
Doses, μg/kg/min | 0.4 [0.2–0.7] | 0.5 [0.2–1] |
Epinephrine | 13 (5) | 13 (5) |
Doses, μg/kg/min | 0.5 [0.2–0.6] | 0.6 [0.3–1] |
Dobutamine | 3 (1) | 4 (2) |
Doses, μg/kg/min | 0.4 [0.3–0.75] | 0.3 [0.18–1.3] |
Mechanical ventilation at day 1 | 127 (49) | |
Mortality at day 14 | 95 (37) | |