Table 6 Intravenous loading dose regimens for treatment, stratified by serum albumin concentration and body mass index, for ≥ 80% probability of achieving total trough concentration ≥ 0.5 mg/L at 48 h
BMI (kg/m2) | Albumin (g/L) | |||
|---|---|---|---|---|
15 | 25 | 35 | 45 | |
17 | 600 mg q12h × 3 | 400 mg q12h × 3 | 300 mg q12h × 3 | 300 mg q12h × 3 |
500 mg q8h × 4 | 300 mg q8h × 4 | |||
24 | > 800 mg q12h × 3 | 500 mg q12h × 3 | 400 mg q12h × 3 | 300 mg q12h × 3 |
700 mg q8h × 4 | 400 mg q8h × 4 | 300 mg q8h × 4 | ||
31 | > 800 mg q8h × 4 | 700 mg q12h × 3 | 500 mg q12h × 3 | 400 mg q12h × 3 |
600 mg q8h × 4 | 400 mg q8h × 4 | 300 mg q8h × 4 | ||
38 | > 800 mg q8h × 4 | 800 mg q12h × 3 | 600 mg q12h × 3 | 500 mg q12h × 3 |
700 mg q8h × 4 | 500 mg q8h × 4 | 400 mg q8h × 4 | ||