Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock

Table 3 Serum and urine pyroglutamic acid, serum and urine glutamic acid, and erythrocyte glutathione peroxidase activity in patients with septic shock compared with healthy control as reference values, and the evolution after 3 days, are shown in this table

	Reference values (n = 28) (mean ± SD)	Case initial (n = 28) (mean ± SD)	Case final (n = 14) (mean ± SD)	P value initial	P value final	P value Case initial—case final
Serum pyroglutamic acid (μg/L)	399.9 ± 77.1	696.7 ± 273.0	992.3 ± 442.6	0.001	0.001	0.075
Urine pyroglutamic acid (μg/L)	400.7 ± 234.5	522.9 ± 356.1	1790.3 ± 431.8	0.153	0.010	0.021
Urine pyroglutamic acid (μg/mg creatinine)	0.40 ± 0.32	2.03 ± 2.29	3.92 ± 1.89	0.001	0.001	0.002
Serum glutamic acid (μg/L)	8.03 ± 2.73	5.74 ± 1.66	7.48 ± 2.26	0.001	0.497	0.190
Urine glutamic acid (μg/L)	30.3 ± 15.7	7.1 ± 4.7	13.2 ± 6.8	0.001	0.001	0.026
Urine glutamic acid (μg/mg creatinine)	0.30 ± 0.18	0.24 ± 0.16	0.53 ± 0.45	0.196	0.103	0.092
Serum selenium (μg/L)	76.93 ± 18.14	56.03 ± 12.95	41.65 ± 11.46	0.001	0.001	0.001
Erythrocyte selenium (μg/L)	108.7 ± 23.3	79.6 ± 14.9	68.2 ± 15.1	0.001	0.001	0.001
Erythrocyte glutathione peroxidase activity (mU/mL)	3980.5 ± 777.5	1265.3 ± 661.5	1412.7 ± 591.4	0.001	0.001	0.154
Erythrocyte glutathione peroxidase activity (U/gr Hb)	26.5 ± 5.1	12.2 ± 6.6	16.2 ± 8.8	0.001	0.001	0.008

Values are expressed as mean ± standard deviation. P (5th and 6th columns) = statistical significance of healthy control as reference values vs cases. P (7th column) = value case initial—case final, show the evolution after 3 days. Fifth and sixth columns show the statistical significance after applying the difference of means for independent samples. The seventh column shows the statistical significance after applying the comparison of means for related samples

ISSN: 1364-8535