Table 2 Initial and final biochemical parameters, and the evolution after 3 days in patients with septic shock
From: Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock
Initial (mean ± SD) n = 28 | Final (mean ± SD) n = 14 | Reference values | P value initial—final | |
|---|---|---|---|---|
pH | 7.32 ± 0.09 | 7.38 ± 0.11 | 7.35–7.45 | 0.354 |
Anion gap (mmol/L) | 12.1 ± 4.2 | 7.2 ± 10.7 | 7–16 | 0.079 |
Lactic acid (mmol/L) | 4.72 ± 1.98 | 2.39 ± 2.17 | 0.6–2.5 | 0.008 |
Creatinine (mg/dL) | 2.99 ± 1.47 | 2.35 ± 1.64 | 0.67–1.20 | 0.097 |
GOT or AST (U/L) | 186.4 ± 299.6 | 964.1 ± 1947.5 | 5–40 | 0.255 |
GPT or ALT (U/L) | 112.6 ± 128.3 | 506.4 ± 779.3 | 13–37 | 0.143 |
Total bilirubin (mg/dL) | 2.37 ± 3.04 | 2.79 ± 3.07 | 0.3–1.2 | 0.431 |
CRP (mg/L) | 35.1 ± 28.9 | 46.7 ± 53.5 | 0.02–5 | 0.679 |
Procalcitonin (ng/mL) | 75.5 ± 59.3 | 42.6 ± 65.9 | < 0.5 | 0.017 |
LDH (U/L) | 620.0 ± 473.8 | 1285.9 ± 2130.7 | 110–295 | 0.211 |
Leukocytes (*103/μL) | 15.3 ± 17.9 | 13.3 ± 68.4 | 3.5–10.5 | 0.816 |
Neutrophils (%) | 84.7 ± 16.2 | 86.1 ± 6.0 | 42–77 | 0.241 |
Hemoglobin (g/dL) | 11.2 ± 2.5 | 9.4 ± 2.1 | 11–17 | 0.001 |
Vitamin B12 (pg/mL) | 976.4 ± 511.0 | 1118.7 ± 192.2 | 116–513 | 0.261 |