Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study

Table 3 Comparison of patient characteristics between non-responders (NR), persistent responders (PR), and transient responders (TR)

Variables	NR (n = 67)	PR (n = 39)	TR (n = 37)	p value for all groups	p value NR vs. PR	p value NR vs. TR	p value PR vs. TR
Age (years)	62.6 ± 13.7	67.7 ± 14.1	64.5 ± 14.1	0.19	0.07	0.50	0.33
SAPS II at admission	48.5 [42.3–57.8]	58 [48–73.5]	55 [45–62]	0.053	0.017	0.23	0.29
SOFA at inclusion	9 [8–11.8]	10 [9–13]	10 [7–11]	0.34	0.14	0.86	0.33
Arterial lactate at baseline (mMol/l)	1.8 [1.3–3.1]	2.55 [1.33–5.43]	1.9 [1.1–3.45]	0.16	0.10	0.78	0.08
ICU mortality rate	25.4%	46.2%	37.8%	0.08	0.048	0.27	0.62
Norepinephrine ≥ 0.5 μg kg⁻¹ min⁻¹	0.34 [0.22–0.67]	0.64 [0.32–1.29]	0.39 [0.20–0.95]	0.07	0.02	0.84	0.13
LVEF				0.88	1.00	0.76	0.73
< 40%	7 (11.1%)	4 (10.5%)	5 (14.3%)
≥ 40%	56 (88.9%)	34 (89.5%)	30 (85.7%)

Continuous data are presented as the mean (SD) or median (IQR). Categorical data are presented as counts (%). For comparison of the NR, TR, and PR groups, a p value < 0.05 was considered as significant. For pairwise comparison, a p value < 0.017 was considered as significant (Bonferroni correction)
SAPS II Simplified Acute Physiology Score II, SOFA Sequential Organ Failure Assessment, ICU intensive care unit, LVEF left ventricular ejection fraction

ISSN: 1364-8535