Table 1 Characteristics of culture-negative and culture-positive sepsis patients
Culture-negative sepsis | Culture-positive sepsis | p | ||
|---|---|---|---|---|
n (%) | 1526 (57.3) | 1133 (42.6) | ||
Group allocation(%) | Control group | 612 (40.1) | 520 (45.9) | 0.003 |
Intervention group | 914 (59.9) | 613 (54.1) | ||
Sex (%) | Female | 663 (43.4) | 467 (41.2) | 0.267 |
Male | 863 (56.6) | 666 (58.8) | ||
Age (median [IQR]) | 75 [65, 83] | 76 [67, 83] | 0.029 | |
Charlson comorbidity index (median [IQR]) | 1 [1, 3] | 1 [0, 3] | 0.754 | |
Antibiotics at home (%) | No | 1183 (77.5) | 903 (79.7) | 0.193 |
Yes | 343 (22.5) | 230 (20.3) | ||
qSOFA in the ambulance (%) | < 2 | 1189 (83.2) | 803 (75.7) | < 0.001 |
≥ 2 | 240 (16.8) | 258 (24.3) | ||
qSOFA in the ED (%) | < 2 | 760 (85.5) | 538 (80.1) | 0.006 |
≥ 2 | 129 (14.5) | 134 (19.9) | ||
Sepsis severity (%) | Sepsis | 648 (43.4) | 353 (31.3) | < 0.001 |
Severe sepsis | 817 (54.8) | 700 (62.1) | ||
Septic shock | 27 (1.8) | 74 (6.6) | ||
Hospital LOS (median [IQR]) | 5 [3, 8] | 7 [4, 11] | < 0.001 | |
CRP (median [IQR]) | 68 [29, 149] | 93 [34, 189] | < 0.001 | |
Source of infection (%) | CNS | 7 (0.5) | 4 (0.4) | < 0.001 |
Intra-abdominal | 82 (5.9) | 95 (8.9) | ||
Line | 1 (0.1) | 3 (0.3) | ||
Pulmonal | 1019 (73.4) | 448 (41.9) | ||
Skin/tissue | 66 (4.8) | 78 (7.3) | ||
Urinary tract | 175 (12.6) | 398 (37.3) | ||
Other | 38 (2.7) | 42 (3.9) | ||
Total number of blood cultures (median [IQR]) | 2 [1, 2] | 2 [2, 4] | < 0.001 | |