Skip to main content

Table 1 Characteristics of culture-negative and culture-positive sepsis patients

From: An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

  Culture-negative sepsis Culture-positive sepsis p
n (%)   1526 (57.3) 1133 (42.6)  
Group allocation(%) Control group 612 (40.1) 520 (45.9) 0.003
Intervention group 914 (59.9) 613 (54.1)
Sex (%) Female 663 (43.4) 467 (41.2) 0.267
Male 863 (56.6) 666 (58.8)
Age (median [IQR])   75 [65, 83] 76 [67, 83] 0.029
Charlson comorbidity index (median [IQR])   1 [1, 3] 1 [0, 3] 0.754
Antibiotics at home (%) No 1183 (77.5) 903 (79.7) 0.193
Yes 343 (22.5) 230 (20.3)
qSOFA in the ambulance (%) < 2 1189 (83.2) 803 (75.7) < 0.001
≥ 2 240 (16.8) 258 (24.3)
qSOFA in the ED (%) < 2 760 (85.5) 538 (80.1) 0.006
≥ 2 129 (14.5) 134 (19.9)
Sepsis severity (%) Sepsis 648 (43.4) 353 (31.3) < 0.001
Severe sepsis 817 (54.8) 700 (62.1)
Septic shock 27 (1.8) 74 (6.6)
Hospital LOS (median [IQR])   5 [3, 8] 7 [4, 11] < 0.001
CRP (median [IQR])   68 [29, 149] 93 [34, 189] < 0.001
Source of infection (%) CNS 7 (0.5) 4 (0.4) < 0.001
Intra-abdominal 82 (5.9) 95 (8.9)  
Line 1 (0.1) 3 (0.3)  
Pulmonal 1019 (73.4) 448 (41.9)  
Skin/tissue 66 (4.8) 78 (7.3)  
Urinary tract 175 (12.6) 398 (37.3)  
Other 38 (2.7) 42 (3.9)  
Total number of blood cultures (median [IQR])   2 [1, 2] 2 [2, 4] < 0.001
  1. qSOFA quick Sequential Organ Failure Assessment score, ED emergency department, LOS length of stay, CRP C-reactive protein, CNS central nervous system