Fig. 3

a, b Cumulative dose of pharmacological agents. We plotted individual cumulative doses of benzodiazepines (panel a) and opioids (panel b) per ICU day. Each dot represents one patient at each time point. The x-axis represents ICU day, and the y-axis the cumulative benzodiazepine or opioid dose. The broken lines represent percentiles of the cumulative doses (10^th, 25^th, 50^th, 75^th, and 90^th percentile, respectively)