Skip to main content

Table 1 (abstract P035). See text for description

From: 39th International Symposium on Intensive Care and Emergency Medicine

Pharmacokinetic parameters

480 mg single dose (n=5)

960 mg single dose (n=8)

3 mg/kg Q2W* (predicted value)

Cmax, mean (SD), μg/mL

132 (39.5)

195 (46.9)

 

C28d, n

4

5

 

C28d, median (range), μg/mL

14.3 (6.51-40.1)

33.1 (6.47-44.8)

 

Ceoi at steady state**, μg/mL

  

117 (56.4-239)

Cmin at steady state**, μg/mL

  

57.7 (19.0-163)

  1. *Predicted values calculated from a population pharmacokinetic model (n=1000) based on ten clinical studies that included 187 Japanese cancer patients. **Median (90% prediction interval). C28d, serum drug concentration on Day 28; Ceoi, end of infusion drug concentration; Cmax, maximum (peak) serum drug concentration; Cmin, minimum (trough) serum drug concentration; SD, standard deviation; Q2W, every two weeks
Back to article page

Critical Care

ISSN: 1364-8535