Table 1 Baseline clinical features and outcomes of patients with N-CLABSI or without N-CLABSI
Features | Patients with N-CLABSI (n = 155) (group A) | Patients without N-CLABSI (n = 4891) (group B*) | Patients with CLABSI (n = 64) (group B-sub) | p value† | |
|---|---|---|---|---|---|
A vs. B | A vs. B-sub | ||||
Age (years), mean ± SD | 53.3 ± 16.4 | 56.9 ± 17.7 | 58.4 ± 16.0 | 0.012 | 0.039 |
Sex, no. male (%) | 110 (71.0) | 3174 (64.9) | 43 (70.5) | 0.118 | 0.945 |
APACHE II score on ICU admission, mean ± SD | 21.0 ± 8.0 | 19.0 ± 8.1 | 22.4 ± 8.5 | 0.002 | 0.272 |
Chronic underlying diseases, no. (%) | 107 (69.0) | 3342 (68.3) | 51 (83.6) | 0.853 | 0.030 |
Diabetes, no. (%) | 30 (19.4) | 619 (12.7) | 18 (29.5) | ||
Hypertension, no. (%) | 35 (22.6) | 1028 (21.0) | 21 (34.4) | ||
Respiratory diseases, no. (%) | 16 (10.3) | 654 (13.4) | 7 (11.5) | ||
Cardiovascular diseases, no. (%) | 27 (17.4) | 744 (15.2) | 15 (24.6) | ||
Renal diseases, no. (%) | 23 (14.8) | 609 (12.5) | 12 (19.7) | ||
Liver diseases, no. (%) | 52 (33.5) | 1147 (23.5) | 26 (42.6) | ||
Malignancies, no. (%) | 18 (11.6) | 1138 (23.3) | 10 (16.4) | ||
Disorder of consciousness, no. (%) | 21 (13.5) | 479 (9.8) | 10 (16.4) | 0.123 | 0.591 |
Gastrointestinal bleeding, no. (%) | 25 (16.1) | 395 (8.1) | 9 (14.8) | < 0.001 | 0.803 |
Trauma, no. (%) | 30 (19.4) | 720 (14.7) | 6 (9.8) | 0.110 | 0.091 |
Immunological diseases, no. (%) | 18 (11.6) | 767 (15.7) | 11 (18.0) | 0.169 | 0.213 |
Organ transplantation, no. (%) | 15 (9.7) | 536 (11.0) | 8 (13.1) | 0.615 | 0.461 |
Multiple organ failure, no. (%) | 62 (40.0) | 1150 (23.5) | 24 (39.3) | < 0.001 | 0.929 |
Shock, no. (%) | 69 (44.5) | 1118 (22.9) | 25 (41.0) | < 0.001 | 0.637 |
Pancreatitis, no. (%) | 70 (45.2) | 597 (12.2) | 30 (32.8) | < 0.001 | 0.097 |
ARDS, no. (%) | 26 (16.8) | 225 (4.6) | 6 (9.8) | < 0.001 | 0.196 |
Surgical operation, no. (%) | 120 (77.4) | 3024 (61.8) | 44 (72.1) | < 0.001 | 0.413 |
Intravascular catheters, no. (%) | 140 (90.3) | 2962 (60.6) | 61 (100.0) | < 0.001 | 0.012 |
Organ biopsy, no. (%) | 31 (3.7) | 812 (16.6) | 17 (27.9) | 0.264 | 0.210 |
MV, no. (%) | 141 (91.0) | 4386 (89.7) | 56 (91.8) | 0.602 | 0.845 |
UC, no. (%) | 148 (95.5) | 4690 (95.9) | 57 (93.4) | 0.152 | 0.539 |
MDRO, no. (%) | 67 (43.2) | 1660 (33.9) | 41 (67.2) | 0.017 | 0.002 |
Sepsis, no. (%) | 38 (24.5) | 332 (6.8) | 11 (18.0) | < 0.001 | 0.306 |
Pneumonia, no. (%) | 108 (69.7) | 2648 (54.1) | 45 (73.8) | < 0.001 | 0.551 |
IAI, no. (%) | 87 (56.1) | 371 (7.6) | 7 (11.5) | < 0.001 | < 0.001 |
HAIs other than NBSIs, pneumonia and IAI, no. (%) | 17 (11.0) | 161 (3.3) | 5 (8.2) | < 0.001 | 0.544 |
Days prior to NBSI date from ICU admission, median (IQR) | 13.0 (8.0–25.0) | NA | 19.0 (12.5–30.0) | NA | 0.031 |
Outcomes | |||||
LOS in ICU after NBSI date (days), median (IQR) | 15.0 (8.0–27.0) | NA | 16.0 (6.0–30.0) | NA | 0.876 |
LOS in hospital after NBSI date (days), median (IQR) | 18.0 (8.0–37.0) | NA | 19.0 (9.5–36.5) | NA | 0.729 |
LOS in ICU (days), median (IQR) | 32.0 (18.0–55.0) | 10.0 (5.0–18.0) | 34.0 (20.0–59.5) | < 0.001 | 0.308 |
LOS in hospital (days), median (IQR) | 42.0 (24.0–68.0) | 21.0 (13.0–33.0) | 39.0 (26.0–77.5) | < 0.001 | 0.533 |
Hospitalization costs (CNY), median (IQR) | 305,074 (196,575–452,309) | 97,591 (57,306–190,754) | 35,9646 (229,092–549,737) | < 0.001 | 0.103 |
Deaths in ICU (mortality) | 39 (25.2) | 637 (13.0) | 20 (32.8) | < 0.001 | 0.258 |
Predicted deaths in ICU (predicted mortality) | 90 (58.1) | 1343 (27.5) | 35 (57.4) | < 0.001 | 0.927 |