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Table 3 Univariate Cox regression for the prediction of 28-day mortality in the derivation and validation cohorts

From: The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study

Biomarker or clinical score

Patients (N)

Mortality (N)

LR χ2

DF

p value

C-index

HR IQR [95% CI]

Derivation cohort

 MR-proADM

1175

84

166.4

1

< 0.001

0.869

5.4 [4.2–6.9]

 PCT

1166

84

42.4

1

< 0.001

0.713

2.1 [1.7–2.6]

 Lactate

746

59

25.3

1

< 0.001

0.678

2.2 [1.6–2.9]

 CRP

1170

83

19.7

1

< 0.001

0.649

2.5 [1.6–3.8]

 SIRS

965

84

12.2

1

< 0.001

0.640

1.9 [1.3–2.8]

 SOFA

1175

84

83.5

1

< 0.001

0.827

2.6 [2.2–3.1]

 qSOFA

1175

84

73.4

1

< 0.001

0.836

3.2 [2.5–4.0]

 NEWS

1058

81

53.0

1

< 0.001

0.734

3.1 [2.3–4.2]

 CRB-65

1175

84

75.8

1

< 0.001

0.838

2.6 [2.1–3.2]

Validation cohort

 MR-proADM

896

45

84.2

1

< 0.001

0.881

3.8 [2.9–5.0]

 PCT

884

45

32.4

1

< 0.001

0.770

2.0 [1.6–2.5]

 CRP

780

42

19.4

1

< 0.001

0.703

3.1 [1.7–5.6]

  1. CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, HR hazard ratio, IQR interquartile range, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment