Multivariable model

Estimate

95% CI

p value


Hypoxemia vs nohypoxemia*

0.74

0.42–1.30

0.296

Hypoxemia vs normoxemia*

0.69

0.39–1.22

0.198

Hyperoxemia vs nohyperoxemia*

1.19

0.78–1.82

0.419

Hyperoxemia vs normoxemia*

1.09

0.71–1.69

0.687

Maximum PaO_{2} difference**

1.01

0.99–1.02

0.436

PaO_{2}TWM T1 to T36**

1.04

0.98–1.10

0.231

PaO_{2}TWM T1 to T12**

1.02

0.98–1.05

0.391

 PaO_{2} arterial partial pressure of oxygen, CI confidence interval, sTau serum Tau, TWM timeweighted mean, T measuring time point in hours after inclusion into the TTM trial, T1 first blood gas analysis after admission but before inclusion. For analyses of categorical data*, the estimate indicates how many times higher the sTau is compared to reference group. For analyses of continuous data**, the estimate indicates how much higher sTau is per 1 kPa PaO_{2} increase