Table 2 Comparison of Patients in PROGRESS with Patients in AQUA and GenIMS
PROGRESS | AQUA | GenIMS | ||
|---|---|---|---|---|
N, number of cases | 1532 | 258,049 | 1886 | |
Age, mean (sd) | 59 (18.3) | 73 (p = 6.9 × 10− 151)1 | 68 (p = 5.1 × 10−67) 1 | |
Age > =60 in % (N) | 55% (836) | 82% (p = 2.1 × 10− 177)2 | NA | |
Male sex | 59% (902) | 57% (p = 0.13)2 | 52% (p = 9 × 10−5)2 | |
Comorbidities and other risk factors | Nursery home resident | 1.5% (23) | 20.7% (p = 8.5 × 10−76)2 | 6.2% (p = 1.7 × 10−11)2 |
Smoking history | 66% (942) | NA | 66% (p = 0.84)2 | |
Antibiotic treatment before admission to hospital, missings excluded | 419 (28%) | NA | NA | |
Antibiotic treatment during the last 5 days, missings excluded | 224 (15%) | NA | NA | |
Antibiosis before admission (in days), mean (sd) median | 0.77 (2.4) 0 | NA | 0.8 (1.4) 0 (p = 0.6169)1 | |
Chron. Lung disease | 30% (458) | NA | 26% (p = 0.014)2 | |
Chron. cardiovascular disease | 26% (399) | NA | 26% (p = 0.70)2 | |
Chron. renal disease | 10% (153) | NA | NA | |
Chron. liver disease | 2.2% (33) | NA | NA | |
Chron. cerebrovascular disease | 5.7% (87) | NA | NA | |
Tumor disease | 8.8% (134) | NA | NA | |
Any of these comorbidities | 52% (789) | NA | NA | |
Chron. bed confinement | 0.9% (14) | 21.4% (p = 2.5 × 10−84)2 | NA | |
Condition/ treatment at enrollment | Disoriented* | 5.8% (88) | 32.7% (p = 4.7 × 10−110)2 | NA |
Low blood pressure*, (Systolic < 90 mmHg or Diastolic < =60 mmHg) | 19% (288) | NA | NA | |
High respiratory rate*, (> = 30 1/min) | 6.6% (62) | NA | NA | |
Vasopressors*, (> = 30 1/min) | 2.9% (44) | NA | NA | |
ICU and ventilation | Mechanical ventilation within 28d, missings treated as ‘No’ | 9.5% (145) | 9.2% (p = 0.1618)2 | 7.3% (p = 0.024)2 |
Mechanical ventilation within 28d, missings excluded | 17.4% (145) | 9.2% (p = 2.8 × 10−20)2 | 7.3% (p = 2.2 × 10− 15)2 | |
ICU within 28d, missings treated as ‘No’ | 17% (259) | NA | 16% (p = 0.51)2 | |
ICU within 28d, missings excluded | 24% (259) | NA | 16% (p = 1.2 × 10−07)2 | |
Scores and Endpoints | Length of hospital stay (LOHS) in (d): mean (sd) median | 10.0 (15.5) 8 | NA | 7.3 (5.0) 6 (p = 9.7 × 10−12) 1 |
LOHS (1–7/8–14/15–21/> 21) in % | 46.3/40.7/7.8/5.2 | 42.5/38.6/10.7/6.8 (p = 1 × 10−04)3 | NA | |
Primary endpoint | 10.1% (155) | NA | NA | |
In-hospital mortality | 2.3% (33) | 13.0% (p = 1.3 × 10−15)2 | NA | |
28-day mortality | 2.3% (35) | NA | NA | |
90-day mortality | 3.5% (54) | NA | 11.5% (p = 2.4 × 10−17)2 | |
CRB-65* (0–4) in % | 41.3/40.3/14.8/3.4/0.1 | 17.2/52.5/23.1/4.5/2.7 (p = 2.1 × 10−88)3 | NA | |
CURB-65* (0–5) in % | 37.0/30.0/21.2/9.2/2.5/0.1 | NA | NA | |
Halm* mean, (sd) | 1.8 (1.1) | NA | NA | |
IDSA/ATS* mean, (sd) | 2.0 (1.4) | NA | NA | |
PSI* (1–5) in % | 23.4/22.9/20.9/23.9/9.0 | NA | 30.7/25.2/33.4/10.8 (p = 1.9 × 10−17)3 | |
qSOFA* (0–3) in % | 44.8/44.8/9.8/0.7 | NA | NA | |
SCAP* mean, (sd) | 7.8 (7.5) | NA | NA | |
SIRS* (1/2/3) in % | 13.2/80.2/6.7 | NA | NA | |
SMART-COP* mean, (sd) | 2.1 (1.6) | NA | NA | |
SOFA* mean, (sd) | 2.9 (2.2) | NA | NA |