Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury

Table 1 Clinical characteristics of 228 critically ill medical ICU patients with severe sepsis

	All patients (N = 228)	With AKI-RRT (N = 80)	Without AKI-RRT (N = 148)	p value
Age (years)	55 ± 16	54 ± 14	56 ± 17	0.639
Male	117 (51)	45 (56)	72 (49)	0.331
APACHE II	32 [29–37]	35 [31–40]	31 [28–35]	< 0.001
Ever smoker	140 (61)	50 (63)	90 (61)	0.887
Alcohol abuse	56 (25)	19 (24)	37 (25)	0.873
Chronic kidney disease	37 (16)	18 (23)	19 (13)	0.063
Vasopressor use	128 (56)	47 (59)	81 (55)	0.579
ARDS development	111 (49)	41 (51)	70 (47)	0.582
Ventilator-free days	19 [0–24]	6 [0–23]	21 [1–25]	0.001
ICU days	8 [5–11]	9 [6–13]	7 [4–11]	0.020
Hospital days	13 [8–22]	16 [9–26]	11 [8–20]	0.013
Died in hospital	83 (36)	38 (48)	45 (30)	0.014
Creatinine (mg/dl)	1.43 [0.92–2.63]	1.98 [1.15–4.06]	1.21 [0.83–2.03]	< 0.001
sVE-cadherin (ng/ml)	2697 [2110–3492]	3052 [2341–3887]	2543 [2058–3410]	0.003

Continuous data are expressed as mean ± standard deviation (SD) or median with interquartile range [IQR] as indicated, and categorical data are expressed as number of patients (%). p value is analyzed by T test (age), chi-square (gender, smoking, alcohol history, chronic kidney disease, vasopressor use, ARDS development, and mortality), or Mann-Whitney U test (APACHE II score, ventilator-free days, ICU days, hospital days, and sVE-cadherin) as appropriate
RRT renal replacement therapy, APACHE II acute physiology and chronic health evaluation II, ARDS acute respiratory distress syndrome, ICU intensive care unit

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