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Table 1 Clinical characteristics of 228 critically ill medical ICU patients with severe sepsis

From: Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury

  All patients (N = 228) With AKI-RRT (N = 80) Without AKI-RRT (N = 148) p value
Age (years) 55 ± 16 54 ± 14 56 ± 17 0.639
Male 117 (51) 45 (56) 72 (49) 0.331
APACHE II 32 [29–37] 35 [31–40] 31 [28–35] < 0.001
Ever smoker 140 (61) 50 (63) 90 (61) 0.887
Alcohol abuse 56 (25) 19 (24) 37 (25) 0.873
Chronic kidney disease 37 (16) 18 (23) 19 (13) 0.063
Vasopressor use 128 (56) 47 (59) 81 (55) 0.579
ARDS development 111 (49) 41 (51) 70 (47) 0.582
Ventilator-free days 19 [0–24] 6 [0–23] 21 [1–25] 0.001
ICU days 8 [5–11] 9 [6–13] 7 [4–11] 0.020
Hospital days 13 [8–22] 16 [9–26] 11 [8–20] 0.013
Died in hospital 83 (36) 38 (48) 45 (30) 0.014
Creatinine (mg/dl) 1.43 [0.92–2.63] 1.98 [1.15–4.06] 1.21 [0.83–2.03] < 0.001
sVE-cadherin (ng/ml) 2697 [2110–3492] 3052 [2341–3887] 2543 [2058–3410] 0.003
  1. Continuous data are expressed as mean ± standard deviation (SD) or median with interquartile range [IQR] as indicated, and categorical data are expressed as number of patients (%). p value is analyzed by T test (age), chi-square (gender, smoking, alcohol history, chronic kidney disease, vasopressor use, ARDS development, and mortality), or Mann-Whitney U test (APACHE II score, ventilator-free days, ICU days, hospital days, and sVE-cadherin) as appropriate
  2. RRT renal replacement therapy, APACHE II acute physiology and chronic health evaluation II, ARDS acute respiratory distress syndrome, ICU intensive care unit