Table 3 Variations in SAP, PP and SVI and slope following sigh application in responders and non-responders
From: Sigh maneuver to enhance assessment of fluid responsiveness during pressure support ventilation
Hemodynamic variables | Responders | Non-responders | p value | AUC (CI95) | ROC-curve sensitivity (%) | ROC-curve specificity (%) | ROC-curve best cutoff |
|---|---|---|---|---|---|---|---|
Sigh15 | |||||||
 Nadir of SAP (%) | −5.8 (− 12.3/−3.2) | −4.8 (−6.5/−2.5) | 0.19 | NA | NA | NA | NA |
 Nadir of PP (%) | −10.7 (− 18.6/−6.0) | −6.3 (− 14.3/−4.1) | 0.10 | NA | NA | NA | NA |
 Nadir of SVI (%) | −1.7 (−2.6/−0.9) | − 1.9 (−2.5/−1.0) | 0.91 | NA | NA | NA | NA |
Sigh25 | |||||||
 Nadir of SAP (%) | − 18.0 (−8.6/− 21.8) | −13.8 (−7.3/−18.3) | 0.004 | 0.77 (0.61–0.93) | 50.0 (29.1–70.8) | 87.5 (61.5–98.4) | −17% |
 Nadir of PP (%) | −23.8 (−15.3/−38.6) | −23.4 (− 12.3/−26.3) | 0.002 | 0.78 (0.63–0.93) | 70.8 (48.9–87.0) | 75.0 (47.6–92.0) | − 17% |
 Nadir of SVI (%) | −1.0 (−9.8/8.2) | −8.7 (−3.2/−15.8) | 0.38 | 0.58 (0.40–0.77) | NA | NA | NA |
Sigh35 | |||||||
 Nadir of SAP (%) | − 24.9 (−19.3/−31.0) | −13.8 (− 7.3/−18.3) | 0.0003 | 0.83 (0.70–0.95) | 62.5 (35.4–84.0) | 91.6 (73.0–98.0) | − 14% |
 Nadir of PP (%) | −38.9 (− 35.1/−53.5) | −23.4 (− 12.3 / -26.3) | <  0.0001 | 0.91 (0.82–0.99) | 75 (47.6–92.7) | 91.6 (73.0–98.9) | −35% |
 Nadir of SVI (%) | −22.8 (− 13.7/−27.5) | −8.7 (− 3.2/−15.8) | 0.0002 | 0.83 (0.71–0.95) | 68.7 (41.3–88.9) | 87.5 (67.4–97.0) | −21% |
Slope | |||||||
 Slope of SAP | −10.4° (− 11.9/−8.6) | −1.5° (− 3.0/−0.20) | <  0.0001 | 0.99 (0.99–1.01) | 100.0 (79.4–100.0) | 95.8 (78.8–99.9) | −4.4° |
 Slope of PP | − 7.6° (− 9.3/−6.4) | −3.7° (− 5.1/−2.1) | <  0.0001 | 0.91 (0.77–0.97) | 68.7 (41.3–88.9) | 95.8 (78.8–99.9) | −7.0° |
 Slope of SVI | −3.3° (− 3.8/−2.2) | −1.5° (− 2.5/−0.9) | <  0.0001 | 0.83 (0.68–0.93) | 56.2 (29.8–80.2) | 91.6 (73.0–98.9) | −3.2° |