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Table 3 Hemodynamic variables during contractility changes

From: Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular systolic function during different experimental loading and contractile conditions

 

Esmolol

Dobutamine

Variables

Before

After

Before

After

CO, Lmin−1

8.87 ± 1.88

5.15 ± 1.09

8.16 ± 2.01

11.23 ± 3.25

SV, ml

116 ± 13

75 ± 11

111 ± 17

131 ± 22

HR, beatsmin− 1

76 ± 10

69 ± 9

73 ± 10

85 ± 15

MAP, mmHg

73 ± 13

50 ± 4

71 ± 8

83 ± 10

EDV, ml

209 ± 33

200 ± 27

210 ± 28

208 ± 29

ESV ml

93 ± 28

125 ± 22

97 ± 23

74 ± 28

LV Ped, mmHg

15 ± 4

13 ± 3*

14 ± 4

15 ± 4

LV Pes, mmHg

76 ± 15

53 ± 8

73 ± 11

85 ± 12

Ea, mmHgml−1

0.53 ± 0.13

0.55 ± 0.12

0.54 ± 0.13

0.55 ± 0.15

Ees, mmHgml− 1

0.37 ± 0.10

0.23 ± 0.06

0.33 ± 0.07

0.50 ± 0.11

LV ejection fraction, %

56 ± 7

38 ± 5

38 ± 5

53 ± 7

SVV, %

9.4 ± 4.4

17.1 ± 3.6

10.1 ± 3.8

8.9 ± 4.2*

LV dP/dtmax, mmHgs− 1

1067 ± 220

485 ± 58

927 ± 174

1701 ± 384

Femoral dP/dmax, mmHgs− 1

292 ± 57

171 ± 44

287 ± 56

392 ± 70

Radial dP/dtmax, mmHgs− 1

401 ± 142

204 ± 66

391 ± 151

565 ± 192

  1. Data are presented as mean ± SD
  2. LV left ventricle, CO cardiac output, SV stroke volume, HR heart rate, MAP mean arterial pressure, EDV left ventricular end-diastolic volume, ESV left ventricular end-systolic volume, LV Ped left ventricular end-diastolic pressure, LV Pes left ventricular end-systolic pressure, Ees end-systolic elastance, Ea effective arterial elastance, SVV stroke volume variation, dP/dtmax peak rate of pressure
  3. *P < 0.05, P ≤ 0.001, P ≤ 0.0001 vs “before” stage