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Table 1 Hemodynamic variables during afterload changes

From: Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular systolic function during different experimental loading and contractile conditions

 

Phenylephrine

Sodium nitroprusside

Variables

Before

After

Before

After

CO, Lmin− 1

7.73 ± 1.40

7.07 ± 1.04*

8.09 ± 1.61

9.89 ± 1.49*

SV, ml

105 ± 11

96 ± 12

103 ± 11

119 ± 15

HR, beatsmin− 1

73 ± 11

73 ± 8

79 ± 11

75 ± 11*

MAP, mmHg

80 ± 9

111 ± 13

81 ± 8

55 ± 4

EDV, ml

218 ± 47

214 ± 45

211 ± 43

212 ± 45

ESV ml

110 ± 42

115 ± 41

105 ± 40

89 ± 43

LV Ped, mmHg

13 ± 4

18 ± 4

12 ± 3

7 ± 3

LV Pes, mmHg

84 ± 11

122 ± 15

90 ± 12

60 ± 7

Ea, mmHgml− 1

0.69 ± 0.13

1.09 ± 0.20

0.77 ± 0.16

0.45 ± 0.09

Ees, mmHgml− 1

0.36 ± 0.12

0.48 ± 0.11

0.41 ± 0.14

0.35 ± 0.14

LV ejection fraction, %

52 ± 10

48 ± 9*

52 ± 10

60 ± 13

SVV, %

10.9 ± 3.6

5.8 ± 2.3

10.9 ± 2.5

21.1 ± 5.9

LV dP/dtmax, mmHgs− 1

1003 ± 158

1245 ± 175

1089 ± 157

963 ± 182*

Femoral dP/dmax, mmHgs− 1

306 ± 52

378 ± 53

335 ± 75

226 ± 52

Radial dP/dtmax, mmHgs− 1

480 ± 110

409 ± 69*

463 ± 125

321 ± 96

  1. Data are presented as mean ± SD
  2. LV left ventricle, CO cardiac output, SV stroke volume, HR heart rate, MAP mean arterial pressure, EDV left ventricular end-diastolic volume, ESV left ventricular end-systolic volume, LV Ped left ventricular end-diastolic pressure, LV Pes left ventricular end-systolic pressure, Ees end-systolic elastance, Ea effective arterial elastance, SVV stroke volume variation, dP/dtmax peak rate of pressure
  3. *P < 0.05, P ≤ 0.001, P ≤ 0.0001 vs “before” stage