Table 3 Comparison of risks from sepsis and death between PA patients and their EH matches, for the whole PA cohort and for the APA subgroup only by target treatments

From: Risk of sepsis in patients with primary aldosteronism

Outcome	Adrenalectomy						MRA
	Crude		Adjust^a		Competing risk^b		Crude		Adjusted^a		Competing risk^b
	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
	PA vs EH						PA vs EH
Sepsis	0.12 (0.04,0.39)	< 0.001	0.13 (0.04,0.41)	0.001	0.14 (0.04,0.44)	0.001	1.53 (1.15,2.04)	0.004	1.52 (1.14,2.03)	0.004	1.49 (1.12,1.98)	0.006
Septic shock	0.12 (0.03,0.49)	0.003	0.13 (0.03,0.53)	0.005	0.14 (0.03,0.55)	0.005	1.25 (0.87,1.81)	0.231	1.24 (0.86,1.80)	0.249	1.22 (0.84,1.76)	0.300
All-cause mortality	0.20 (0.12,0.33)	< 0.001	0.21 (0.13,0.36)	< 0.001	N/A	N/A	1.06 (0.89,1.26)	0.526	1.05 (0.88,1.25)	0.606	N/A	N/A
	APA vs EH						APA vs EH
Sepsis	0.14 (0.04,0.45)	0.001	0.14 (0.04,0.46)	0.001	0.16 (0.05,0.53)	0.003	0.55 (0.23,1.35)	0.193	0.55 (0.22,1.33)	0.184	0.44 (0.18,1.07)	0.071
Septic shock	0.14 (0.03,0.60)	0.008	0.14 (0.03,0.61)	0.009	0.16 (0.04,0.67)	0.012	0.59 (0.20,1.78)	0.352	0.57 (0.19,1.70)	0.314	0.46 (0.15,1.36)	0.160
All-cause mortality	0.25 (0.14,0.43)	< 0.001	0.25 (0.15,0.44)	< 0.001	N/A	N/A	0.42 (0.24,0.76)	0.004	0.40 (0.22,0.72)	0.002	N/A	N/A

APA aldosterone-producing adenoma, CI confidence interval, EH essential hypertension, MRA mineralocorticoid antagonist, NA nonavailable, PA primary aldosteronism
^aMultivariate Cox regression model selected covariates from all variables presented in Table 1 by a stepwise procedure. This model constructed adrenalectomy, steroid, and potassium supplement for hypokalemia as time-varying covariates
^bCompeting risk regression model included age, gender, and propensity score as covariates

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