Risk of sepsis in patients with primary aldosteronism

Table 2 Incidence and risks for outcomes of interest between PA patients and their EH matches, for the whole PA cohort and for the APA subgroup only

Outcome							Crude		Adjusted^a		Competing risk^b
	Events	Person-years	Incidence rate per 1000 person-years	Events	Person-years	Incidence rate per 1000 person-years	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
	PA			EH			PA vs EH
Sepsis	104	13,652.95	7.6	87	13,144.31	6.6	1.15 (0.87, 1.53)	0.332	1.17 (0.88, 1.55)	0.286	1.18 (0.89, 1.57)	0.250
Septic shock	57	13,772.55	4.1	58	13,211.21	4.4	0.94 (0.65, 1.36)	0.754	0.96 (0.66, 1.38)	0.816	0.96 (0.67, 1.39)	0.850
All-cause mortality	236	13,836.93	17.1	273	13,268.23	20.6	0.83 (0.70, 0.99)	0.035	0.84 (0.71, 1.00)	0.050	N/A	N/A
	APA			EH			APA vs EH
Sepsis	9	5550.02	1.6	29	5104.02	5.7	0.28 (0.13, 0.59)	0.001	0.28 (0.13, 0.59)	0.001	0.29 (0.14, 0.61)	< 0.001
Septic shock	6	5556.85	1.1	19	5122.85	3.7	0.28 (0.11, 0.71)	0.007	0.28 (0.11, 0.71)	0.007	0.30 (0.12, 0.75)	0.010
All-cause mortality	28	5567.03	5	84	5141.56	16.3	0.31 (0.20, 0.47)	< 0.001	0.31 (0.20, 0.47)	< 0.001	N/A	N/A

APA aldosterone-producing adenoma, CI confidence interval, EH essential hypertension, NA nonavailable, PA primary aldosteronism
^*Multivariate Cox regression model selected covariates from all variables presented in Table 1 by a stepwise procedure
^bCompeting risk regression model included age, gender, and propensity score as covariates

ISSN: 1364-8535