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Table 2 Changes in clinical and biochemical parameters after TPE

From: Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers

Variable

Therapeutic plasma exchange (TPE)

p value

Before

After

Clinical parameters

 MAP (mmHg)

65.5 (54.5–75.3)

69 (64–79.3)

0.07

 NE dose (μg/kg/min)

0.82 (0.61–1.17)

0.56 (0.41–0.78)

0.0002*

 MAP/NE (mmHg/μg/kg/min)

74.9 (48.5–116.8)

114.3 (75.3–166.7)

< 0.0001*

 HR (bpm)

110.5 (91.3–125.5)

103.5 (86.8–119)

0.11

 SVV (%)

20 (12.5–29)

11 (6–14.5)

0.008*

 SVRI (dyne/s/cm5/m2)

1450 (980–1873)

1520 (1060-2126)

0.67

 SVRI/NE (dyne/s/cm5/m2)/(μg/kg/min)

1743 (1008-2921)

2547 (1213-3923)

0.06

 EVLWI (mL/kg)

14 (8–17)

11.5 (8–16.5)

0.93

 GEDI (mL/m2)

670 (483–909)

755 (622–998)

0.12

 Cardiac index (L/min/m2)

2.85 (2.39–4.32)

3.42 (2.71–5.19)

0.39

 Fluid balance/6 h (mL)

3411 (2295-4933)

2190 (1431-4060)

0.007*

Gas exchange

 Oxygenation index (PaO2/FiO2)

132 (96–229)

115 (102–212)

0.94

 AaDO2 (mmHg)

360 (251–541)

329 (247–489)

0.28

Inflammatory biomarkers

 CRP (mg/L)

236 (147–302)

174 (86–288)

0.07

 PCT (ng/mL)

24.1 (16.9–83.7)

31 (14.8–87.3)

0.86

 WBC (1/nL)

11.2 (0.93–34.8)

8.4 (1.2–25.6)

0.73

 PLT (1/nL)

43.0 (16.8–112)

34.0 (20–66)

0.11

 INR

1.76 (1.44–2.1)

1.43 (1.26–2.1)

0.16

Acid base balance

 pH

7.28 (7.19–7.34)

7.33 (7.23–7.38)

0.01*

 pCO2 (mmol/L)

44.5 (35.3–56.3)

46 (37–55)

0.99

 HCO3− (mmol/L)

20.0 (17–23.8)

22.0 (20–24.7)

0.001*

 Lactate (mmol/L)

6.5 (2.8–11.3)

6.5 (3.2–10.8)

0.84

Cytokines

 IL-8 (ng/mL)

1.35 (0.6–10.81)

1.09 (0.4–7.1)

0.009*

 IL-1b (pg/mL)

147.1 (57.1–241.6)

92.2 (42.9–184.8)

0.01*

 IL-6 (ng/mL)

10.8 (2.54–27.6)

4.6 (0.9–13.7)

0.005*

 IL-10 (pg/mL)

143.3 (65.5–259.2)

98.1 (59.6–180.4)

0.05

Vasoactive substances

 Angiopoietin-1 (ng/mL)

3.27 (2.01–5.36)

2.97 (1.42–5.15)

0.1

 Angiopoietin-2 (ng/mL)

9.51 (5.06–13.2)

5.14 (3.04–11.18)

< 0.0001*

 sTie2 (ng/mL)

16.03 (10.91–19.51)

8.36 (6.67–12.85)

< 0.0001*

  1. Values are shown as median (interquartile range)
  2. AaDO2 alveolar-arterial oxygen difference, CRP C-reactive protein, EVLWI extravascular lung water index, GEDI global end-diastolic index, HCO3− arterial bicarbonate concentration, HR heart rate, IL interleukin, INR international normalized ratio, MAP mean arterial pressure, NE norepinephrine, pCO2 arterial partial pressure of carbon dioxide, PCT procalcitonin, PLT platelet count, sTie2 soluble receptor of tyrosine kinase with immunoglobulin-like and EGF-like domains 2, SVRI systemic vascular resistance index, SVV stroke volume variance, WBC white blood cell count
  3. *Significant p values
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Critical Care

ISSN: 1364-8535