Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model

Table 2 Incidence and definition of each of the components of the primary outcome

	Definition	Total (n = 769), n (%)
Total women with primary outcome		127 (16.5%)
Maternal death	Death during or within 42 days of delivery	59 (7.7%)
Maternal Morbidity	Occurrence of one or more of the defined organ support measures below	97 (12.6%)
Organ support
Respiratory	Need for CPAP, BiPAP, or invasive ventilation	73
Cardiovascular	Need for use of inotropes or vasopressors	15
Renal	Renal replacement therapy for acute renal failure	14
Hepatic	Liver transplantation. Other management of hepatic failure include ventilatory and circulatory support, management of elevated intracranial pressure and renal failure, medical therapies for hepatitis B virus (lamivudine); anticoagulation for Budd–Chiari syndrome.	21
Hematological	Massive transfusion of at least 5 units of blood products	60
Neurological	GCS score of less than 10	35
Uterine	Uncontrollable hemorrhage or infection leading to life-saving hysterectomy	16

Abbreviations: BiPAP bilevel positive airway pressure, CPAP continuous positive airway pressure, GCS Glasgow Coma Scale
Maternal morbidities presented are not mutually exclusive and include those occurring in women who died. Morbidities have been grouped by organ system. All organ system outcomes required use of life-saving treatment for more than 7 days to meet outcome criteria with the exception of hematological and uterine support.

ISSN: 1364-8535