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Table 5 Cox regression analyses for 90-day mortality with cumulative fluid balance, cumulative input, and output

From: Permissive fluid volume in adult patients undergoing extracorporeal membrane oxygenation treatment

Models Variables Cardiovascular disease Non-cardiovascular disease
HR (95% CI) P value HR (95% CI) P value
Model 1 CFB* 1.76 (1.37–2.27) < 0.001 1.46 (1.17–1.83) < 0.001
Model 2 CFB* 1.67 (1.19–2.34) 0.003 1.55 (1.16–2.09) 0.003
Model 3 Cumulative input*,† 3.35 (1.64–6.83) 0.001 5.53 (2.60–11.75) < 0.001
Cumulative total output*,† 0.56 (0.47–0.76) < 0.001 0.25 (0.14–0.45) < 0.001
Model 4 Cumulative input*,† 2.66 (1.30–5.44) 0.007 1.92 (1.08–3.42) 0.027
Cumulative urine output*,† 0.78 (0.67–0.91) 0.001 0.84 (0.75–0.93) 0.001
  1. CFB Cumulative fluid balance
  2. Model 1: Additionally adjusted for age, sex, Charlson comorbidity index, Acute Physiology and Chronic Health Evaluation II score, and propensity score
  3. Model 2: Model 1 + daily fluid balance before ECMO*
  4. Model 3: Model 2 + cumulative input + cumulative total output without CFB
  5. Model 4: Model 2 + cumulative input + cumulative urine output without CFB
  6. *Data were log-transformed
  7. During 3 days from extracorporeal membrane oxygenation (ECMO) commencement
  8. Daily fluid balance during intensive care unit admission before ECMO commencement
  9. Propensity score was obtained by logistic regression analysis with covariables body mass index, ECMO pump time, ECMO blood flow rate, albumin, total carbon dioxide, acute kidney injury stage
  10. The 27 (3.7%) patients who were lost to follow-up were treated as censored